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Table 3 Factors associated with the rate of statin non-adherence (n =12,100)

From: Statin initiation and treatment non-adherence following a first acute myocardial infarction in patients with inflammatory rheumatic disease versus the general population

  Hazard ratio 95% CI P-value
Inflammatory rheumatic disease 1.11 0.82, 1.52 0.49
Age group, years    
<50 1 - -
50 to 59 0.80 0.72, 0.89 <0.001
60 to 69 0.67 0.59, 0.75 <0.001
70 to 79 0.58 0.51, 0.66 <0.001
80+ 0.49 0.42, 0.58 <0.001
Female 0.97 0.89, 1.06 0.49
Indigenous 2.01 1.69, 2.41 <0.001
Married/de-facto 0.91 0.84, 0.99 0.03
Remote1 1.02 0.86, 1.22 0.86
Lowest quartile of Socio-Economic Indexes for Areas Index of Relative Socio-Economic Disadvantage (SEIFA-IRSD) 1.12 0.97, 1.30 0.12
Elective admission 0.87 0.75, 1.01 0.06
Intensive Care Unit during admission 0.98 0.87, 1.09 0.65
Hospital type    
Tertiary 1 - -
Public metro 0.92 0.65, 1.31 0.64
Rural public/private 0.88 0.77, 0.99 0.04
Private metro 1.00 0.89, 1.13 0.94
Comorbidities at index admission2    
Cancer 1.09 0.77, 1.53 0.63
Cerebral vascular accident 0.80 0.58, 1.09 0.16
Dementia 1.04 0.60, 1.81 0.88
Diabetes 1.02 0.91, 1.14 0.72
HIV - - -
Liver disease 1.51 0.63, 3.63 0.36
Paraplegia 0.92 0.56, 1.53 0.76
Peptic ulcer 1.29 0.86, 1.94 0.21
Pulmonary disease 1.06 0.87, 1.29 0.57
Peripheral vascular disease 1.02 0.78, 1.35 0.87
Renal Disease 1.00 0.84, 1.19 0.96
Cardiovascular Risk factors    
Smoker 1.17 1.07, 1.27 <0.001
Hypertension 1.06 0.98, 1.14 0.15
Hypercholesterolaemia 1.03 0.95, 1.11 0.54
Obesity 1.15 1.01, 1.30 0.03
Count of PBS medications at 3 months post MI    
0 to 1 1 - -
2 to 5 0.76 0.60, 0.96 0.02
6 to 10 0.70 0.55, 0.89 <0.01
>10 0.68 0.52, 0.87 <0.01
Statin use within 12 months prior to index MI 0.90 0.82, 0.98 0.02
  1. Analysis of factors was based on a competing risk, Cox Regression Model, adjusting for death for all patients initiated on statins. 1Based on ARIA Code =4, excluding those deceased within 3 months, unlimited follow-up. 2Based on Charlson comorbidity components. Bolded text indicates statistically significant factors (P <0.05). PBS, Pharmaceutical Benefits Scheme; MI, myocardial infarction.