Skip to main content

Table 2 Gene-based tests of rare nonsynonymous variants in RA

From: Targeted exon sequencing fails to identify rare coding variants with large effect in rheumatoid arthritis

GENE

Chr

Gene-based test*

Nmarker

SKAT-O (nonburden test)Pvalue

SCORE_seq (burden test)

Pvalue

VSTM1

19

7

4.55 × 10-3

7.80 × 10-4

KPRP

1

8

6.38 × 10-3

6.51× 10-3

C6orf99

6

5

0.05155

0.01669

PARD3

10

21

0.14496

0.01887

PYGL

14

10

0.02287

0.02057

ARHGAP26

5

9

0.01939

0.02114

NCF2

1

8

0.02574

0.02159

CCR6

6

7

0.01131

0.02776

TRAF6

11

8

0.04621

0.02876

GRIN2B

12

6

0.20806

0.02966

SNTB1

8

6

0.00987

0.03395

PTCD3

2

11

0.14462

0.03772

CA8

8

3

0.17982

0.03792

NRXN3

14

8

0.12536

0.03905

CPEB4

5

7

0.05104

0.04010

CTNNA3

10

16

0.10312

0.04079

KRT24

17

5

0.02866

0.04837

  1. *We defined rare nonsynonymous variants as MAF <5% in both cases and controls. We selected 347 genes with two or more rare nonsynonymous variants for gene-based tests. RA, rheumatoid arthritis; Chr, chromosome; Nmarker, number of rare nonsynonymous variants for each gene.
Back to article page

Arthritis Research & Therapy

ISSN: 1478-6362

Contact us