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Figure 4 | Arthritis Research & Therapy

Figure 4

From: Subchondral bone influences chondrogenic differentiation and collagen production of human bone marrow-derived mesenchymal stem cells and articular chondrocytes

Figure 4

Immunofluorescence staining of collagens. Representative immunofluorescence staining of collagens I (A), II (B), III (C) and X (D) and of Alcian blue (E) in fibrin gels of BMSC, mixed cultures (BMSC + chondrocytes 1:1) and chondrocytes after 28 days of co- and triculture with OAB (FB) or monoculture (F) (Scale bar is 100 μm). BMSC, bone marrow-derived mesenchymal stem cells; F, fibrin gel-embedded monocultures (without subchondral bone explants); FB, fibrin gel-embedded co- and tricultures together with subchondral bone explants; OAB, osteoarthritic subchondral bone.

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