Table 3 Disease activity, bone mineral density and laboratory variables in patients with juvenile idiopathic arthritis during tumour necrosis factor α blocker treatment and in control participants ^a

hsCRP (mg/L)

12.09^b

5.19^b

4.28^b

0.73

(6.28 to 25.17)

(1.30 to 12.89)

(0.89 to 13.44)

(0.27 to 1.78)

ESR (mm/hr)

25.50^b

16.00^b

12.00^b,c

4.00

(20.00 to 36.00)

(4.00 to 24.00)

(4.00 to 26.00)

(2.00 to 8.00)

DAS28

6.26

2.93^c

2.51^c

(5.87 to 6.82)

(1.13 to 3.69)

(1.25 to 3.64)

Swollen joints (n)

12.0

0.0^c

0.0^c

(9.0 to 15.5)

(0.0 to 2.0)

(0.0 to 2.0)

Tender joints (n)

15.0

1.0^c

0.0^c

(11.3 to 17.8)

(0.0 to 2.0)

(0.0 to 2.0)

PGH (mm)

69.0

18.0^c

10.0^c

(59.0 to 75.0)

(5.0 to 27.8)

(0 to 20.0)

Lumbar spine BMD (g/cm²)

1.065^b

1.089^b,c

1.093^b,c

1.209

(0.972 to 1.221)

(1.044 to 1.248)

(1.053 to 1.161)

(1.175 to 1.279)

Femur total BMD (g/cm²)

0.909^b

0.918^b

0.886^b

1.134

(0.776 to 0.984)

(0.776 to 1.015)

(0.790 to 0.996)

(1.061 to 1.202)

Femoral neck BMD (g/cm²)

0.899^b

0.903^b

0.905^b

1.118

(0.819 to 1.017)

(0.806 to 1.033)

(0.821 to 1.019)

(1.042 to 1.201)

Distal forearm BMD (g/cm²)

0.690

0.712

0.707

0.713

(0.614 to 0.761)

(0.638 to 0.769)

(0.632 to 0.762)

(0.676 to 0.768)

Osteocalcin (μg/L)

17.75

17.45

15.20

21.20

(12.40 to 24.80)

(8.80 to 26.90)

(11.95 to 20.20)

(16.68 to 26.90)

PINP (μg/L)

46.16

46.41

51.23

50.96

(31.96 to 59.41)

(32.01 to 88.77)

(33.66 to 72.01)

(37.10 to 81.84)

βCTX-I (μg/L)

0.35

0.33

0.33^b

0.46

(0.18 to 0.52)

(0.23 to 0.49)

(0.20 to 0.45)

(0.34 to 0.70)

sRANKL (pmol/L)

0.08

0.05

0.07

0.06

(0.02 to 0.25)

(0.00 to 0.25)

(0.00 to 0.21)

(0.00 to 0.16)

OPG (pmol/L)

3.84

3.26

3.02

3.14

(2.53 to 4.84)

(2.10 to 3.64)

(2.03 to 3.55)

(2.62 to 3.85)

sRANKL/OPG ratio

0.03

0.03

0.01

0.02

(0.01 to 0.07)

(0.00 to 0.10)

(0.00 to 0.10)

(0.00 to 0.05)

Dkk1 (pmol/L)

28.74

24.08

21.52^b,c

28.74

(23.8 to 36.84)

(14.54 to 29.41)

(15.72 to 31.25)

(23.80 to 36.84)

Sclerostin (μg/L)

7.42^b

2.06^c

1.22^c

1.94

(3.57 to 15.49)

(1.00 to 3.48)

(0.30 to 3.26)

(0.62 to 5.71)