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Table 4 DAVID functional annotation clusters of upregulated or downregulated mRNAs in at least four of five degenerative specimens

From: Aberrantly expressed long noncoding RNAs in human intervertebral disc degeneration: a microarray related study

Annotation clusters Cluster-related terms Enrichment score
Most significant functional clusters for the mRNAs upregulated in at least four of the five degenerative samples
1 Nucleosome core, protein-DNA complex, chromatin assembly, et cetera 3.91
2 Glycosaminoglycan binding, polysaccharide binding, pattern binding, et cetera 3.89
3 Ribosome, translational elongation, cytosolic ribosome 3.63
4 Histone H2A 2.78
5 Basic-leucine zipper domain, DNA-binding region: basic motif 2.58
Most significant functional clusters for the mRNAs downregulated in at least four of the five degenerative samples
1 Negative regulation of gene expression, negative regulation of transcription, negative regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolic process, et cetera 1.60
2 Cytosolic ribosome, ribosome, ribosomal subunit, et cetera 1.51
3 Phosphoglycerate mutase, Tele-phosphohistidine intermediate, Phosphoglycerate mutase, et cetera 1.49
4 Purine nucleotide biosynthetic process, purine nucleotide metabolic process, nucleotide biosynthetic process, et cetera 1.44
5 Proteasomal ubiquitin-dependent protein catabolic process, proteasomal protein catabolic process, ubiquitin-dependent protein catabolic process, et cetera 1.40