Table 4 DAVID functional annotation clusters of upregulated or downregulated mRNAs in at least four of five degenerative specimens
Annotation clusters | Cluster-related terms | Enrichment score |
|---|---|---|
Most significant functional clusters for the mRNAs upregulated in at least four of the five degenerative samples | ||
1 | Nucleosome core, protein-DNA complex, chromatin assembly, et cetera | 3.91 |
2 | Glycosaminoglycan binding, polysaccharide binding, pattern binding, et cetera | 3.89 |
3 | Ribosome, translational elongation, cytosolic ribosome | 3.63 |
4 | Histone H2A | 2.78 |
5 | Basic-leucine zipper domain, DNA-binding region: basic motif | 2.58 |
Most significant functional clusters for the mRNAs downregulated in at least four of the five degenerative samples | ||
1 | Negative regulation of gene expression, negative regulation of transcription, negative regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolic process, et cetera | 1.60 |
2 | Cytosolic ribosome, ribosome, ribosomal subunit, et cetera | 1.51 |
3 | Phosphoglycerate mutase, Tele-phosphohistidine intermediate, Phosphoglycerate mutase, et cetera | 1.49 |
4 | Purine nucleotide biosynthetic process, purine nucleotide metabolic process, nucleotide biosynthetic process, et cetera | 1.44 |
5 | Proteasomal ubiquitin-dependent protein catabolic process, proteasomal protein catabolic process, ubiquitin-dependent protein catabolic process, et cetera | 1.40 |