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Table 2 Tumor necrosis factor/tumor necrosis factor receptor family members and functions

From: Immune checkpoint receptors in regulating immune reactivity in rheumatic disease

Molecule Expression Ligand/receptor Function
DR3 Lymphocytes Tumor necrosis factor-like cytokine 1A (TL1A) expressed on APCs [4] Delivers a co-inhibitory signal, induces cell survival, prevents apoptosis [4],[5]
4-1BB/CD137 Activated T cells, Tregs, DCs and B cells 4-1BB ligand on DCs and B cells [6] 4-1BB induces CD8+ T-cell, NK T-cell and B-cell survival [6]
    Signaling back via 4-1BB ligand induces monocyte activation [6]
OX40/CD134 Activated T cells OX40 ligand/CD252 on B cells, endothelial cells, DCs and macrophages OX40 increases CD4+ T-cell survival/effector function [6]
    OX40 impacts immunoregulation by reducing interleukin-10 production by Tr1 and CD4+ Tregs [6]
CD27 Naïve T-cells, memory B cells, NK T cells, NK cells [6] CD70 on activated lymphocytes and DCs CD27-CD70 signaling on B cells propagates germinal center formation and plasma cell activities
    Signaling on T cells results in proliferation and cytokine production [6]
CD40 B cells CD154/CD40 ligand on T cells, T follicular helper cells, endothelial and epithelial cells, B cells or APCs [7] CD154+ T cells permit germinal center formation
    Signaling via CD40 on B cells induces B-cell differentiation, isotype switching and proliferation [7]
    Signaling via CD40 on APCs, increases CD80 and CD86 expression [7]
  1. APC, antigen presenting cell; DC, dendritic cell; NK, natural killer; Treg, regulatory T cell.