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Figure 3 | Arthritis Research & Therapy

Figure 3

From: Regulatory T cells and control of the germinal centre response

Figure 3

Follicular regulatory T cells control the output of the germinal centre response. Direct suppression of germinal centre B cells might occur through cytotoxic T-lymphocyte antigen 4 (CTLA-4)-mediated inhibition of CD80/CD86 co-stimulatory signalling. Alternatively, follicular regulatory T (Tfr) cell-mediated suppression may take place in an indirect manner by means of IL-10 secretion acting on follicular helper T (Tfh) cells. DZ, dark zone; FDC, follicular dendritic cells; LZ, light zone.

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