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Figure 4 | Arthritis Research & Therapy

Figure 4

From: Platelets induce a proinflammatory phenotype in monocytes via the CD147 pathway in rheumatoid arthritis

Figure 4

High MPA levels and positive correlations with Mon2 and with the expression of CD147 on platelets and Mon2. (A) The percentages of platelets that aggregated with monocytes and (B) the monocyte subsets in healthy controls (n = 10), patients with inactive RA (n = 10) and patients with active RA (n = 30). MPA levels (C) vs. the percentage of Mon2 (r = 0.66, P <0.0001), (D) vs. the expression of CD147 on platelets (r = 0.61, P = 0.0004) and (E) vs. the expression of CD147 on Mon2 monocytes (r = 0.77, P <0.0001) within the group of patients with active RA (means ± SDs of the mean, *P <0.05, **P <0.001 and ***P <0.0001 vs. corresponding controls). HD: healthy donors; P: platelet; MPA: monocyte-platelet aggregates; Mon1: CD14++CD16CCR2+; Mon2: CD14++CD16+CCR2+; Mon3: CD14+CD16++CCR2; RA: rheumatoid arthritis.

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