Table 3 Analysis of FCN2 polymorphisms in SSc cases and controls
Variables | Cases | Controls | Univariate matched analysis | |
|---|---|---|---|---|
(n = 90) | (n = 90) | OR (95% CI) | Pvalue | |
FCN2 promoter variants, n (%) | Â | Â | Â | Â |
 FCN2 -986, n (%) |  |  |  |  |
  G/G | 27 (30) | 22 (24) | Reference |  |
  G/A | 39 (43) | 44 (49) | 0.7 (0.3-1.5) | 0.4 |
  A/A | 24 (27) | 24 (27) | 0.8 (0.4-1.7) | 0.6 |
 FCN2 - 602, n (%) |  |  |  |  |
  G/G | 57 (63) | 63 (70) | Reference |  |
  G/A | 25 (28) | 23 (26) | 1.1 (0.6-2.3) | 0.7 |
  A/A | 8 (9) | 4 (4) | 2.0 (0.6-6.7) | 0.25 |
 FCN2 - 557, n (%) |  |  |  |  |
  A/A | 65 (72) | 76 (84) | Reference |  |
  A/G | 23 (26) | 13 (14) | 2.1 (1.0-4.7) | 0.07 |
  G/G | 2 (2) | 1 (1) | 2 (0.2-22.0) | 0.6 |
 FCN2 - 4, n (%) |  |  |  |  |
  A/A | 53 (59) | 41 (46) | Reference |  |
  A/G | 35 (39) | 41 (46) | 0.7 (0.4-1.2) | 0.18 |
  G/G | 2 (2) | 8 (9) | 0.2 (0.04-0.99) | 0.048 |
FCN2 exon variants, n (%) | Â | Â | Â | Â |
 FCN2 + 6359, n (%) |  |  |  |  |
  C/C | 49 (54) | 40 (44) | Reference |  |
  C/T | 39 (44) | 40 (44) | 0.8 (0.4-1.4) | 0.4 |
  T/T | 2 (2) | 10 (11) | 0.2 (0.04-0.8) | 0.03 |
 FCN2 + 6424, n (%) |  |  |  |  |
  G/G | 65 (72) | 74 (82) | Reference |  |
  G/T | 22 (24) | 15 (17) | 1.6 (0.8-3.2) | 0.2 |
  T/T | 3 (3) | 1 (1) | 3.4 (0.4-33.0) | 0.3 |
FCN2 haplotypes, n (%) | Â | Â | Â | Â |
  GGAACG | 31 (35) | 37 (41) | Reference |  |
  AGAGTG | 18 (20) | 26 (30) | 0.6 (0.4-1.1) | 0.1 |
  AAAACG | 19 (22) | 14 (15) | 1.4 (0.8-2.4) | 0.3 |
  GGGACT | 11 (13) | 7 (7) | 1.7 (0.7-3.8) | 0.2 |
  AGAACG | 4 (4) | 2 (2) | 1.7 (0.5-5.0) | 0.4 |