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Table 3 Analysis of FCN2 polymorphisms in SSc cases and controls

From: Potential role of the lectin pathway of complement in the pathogenesis and disease manifestations of systemic sclerosis: a case-control and cohort study

Variables Cases Controls Univariate matched analysis
(n = 90) (n = 90) OR (95% CI) Pvalue
FCN2 promoter variants, n (%)     
FCN2 -986, n (%)     
  G/G 27 (30) 22 (24) Reference  
  G/A 39 (43) 44 (49) 0.7 (0.3-1.5) 0.4
  A/A 24 (27) 24 (27) 0.8 (0.4-1.7) 0.6
FCN2 - 602, n (%)     
  G/G 57 (63) 63 (70) Reference  
  G/A 25 (28) 23 (26) 1.1 (0.6-2.3) 0.7
  A/A 8 (9) 4 (4) 2.0 (0.6-6.7) 0.25
FCN2 - 557, n (%)     
  A/A 65 (72) 76 (84) Reference  
  A/G 23 (26) 13 (14) 2.1 (1.0-4.7) 0.07
  G/G 2 (2) 1 (1) 2 (0.2-22.0) 0.6
FCN2 - 4, n (%)     
  A/A 53 (59) 41 (46) Reference  
  A/G 35 (39) 41 (46) 0.7 (0.4-1.2) 0.18
  G/G 2 (2) 8 (9) 0.2 (0.04-0.99) 0.048
FCN2 exon variants, n (%)     
FCN2 + 6359, n (%)     
  C/C 49 (54) 40 (44) Reference  
  C/T 39 (44) 40 (44) 0.8 (0.4-1.4) 0.4
  T/T 2 (2) 10 (11) 0.2 (0.04-0.8) 0.03
FCN2 + 6424, n (%)     
  G/G 65 (72) 74 (82) Reference  
  G/T 22 (24) 15 (17) 1.6 (0.8-3.2) 0.2
  T/T 3 (3) 1 (1) 3.4 (0.4-33.0) 0.3
FCN2 haplotypes, n (%)     
  GGAACG 31 (35) 37 (41) Reference  
  AGAGTG 18 (20) 26 (30) 0.6 (0.4-1.1) 0.1
  AAAACG 19 (22) 14 (15) 1.4 (0.8-2.4) 0.3
  GGGACT 11 (13) 7 (7) 1.7 (0.7-3.8) 0.2
  AGAACG 4 (4) 2 (2) 1.7 (0.5-5.0) 0.4
  1. CI, confidence interval; FCN2, ficolin-2; OR, odds ratio; SD, standard deviation; SSc, systemic sclerosis.