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Figure 5 | Arthritis Research & Therapy

Figure 5

From: Local intra-articular injection of rapamycin delays articular cartilage degeneration in a murine model of osteoarthritis

Figure 5

The effect of rapamycin on matrix metallopeptidase 13 (MMP13) expression in articular cartilage. (A) Representative images of immunostaining for MMP13 (green). Scale bar = 20 μm. (B) Quantification of MMP13-positive cells in the cartilage was calculated. (C) Graph indicating quantitative RT-PCR for MMP13 in dimethyl sulphoxide (DMSO)- and rapamycin-treated mice 8 and 12 weeks after destabilization of the medial meniscus (DMM) injury. ***P <0.001, **P <0.01.

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