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Table 3 Comparison of patients RF or ACPA negative to those with low and high RF or ACPA levels

From: Rheumatoid factor and anti-citrullinated protein antibody positivity, but not level, are associated with increased mortality in patients with rheumatoid arthritis: results from two large independent cohorts

 

NOAR

Leiden EAC

 

Total EIA population

2010 ACR/EULAR positive cohort

Total EIA population

2010 ACR/EULAR positive cohort

Model/predictor

HR

95% CI

HR

95% CI

HR

95% CI

HR

95% CI

RF:

        

Unadjusted a

        

RF low positive

0.90

0.68 to 1.20

0.90

0.66 to 1.24

2.13

1.55 to 2.91

1.75

1.21 to 2.54

RF high positive

1.67

1.41 to 1.97

1.43

1.18 to 1.74

1.75

1.33 to 2.31

1.39

0.99 to 1.93

Age and sex adjusted a

        

RF low positive

0.81

0.61 to 1.08

0.80

0.58 to 1.10

1.67

1.21 to 2.29

1.67

1.15 to 2.42

RF high positive

1.54

1.30 to 1.82

1.33

1.09 to 1.62

1.92

1.46 to 2.53

2.00

1.42 to 2.81

Multivariate ab

        

RF low positive

0.80

0.59 to 1.08

0.85

0.61 to 1.18

1.62

1.16 to 2.26

1.57

1.07 to 2.32

RF high positive

1.49

1.25 to 1.77

1.40

1.14 to 1.71

1.63

1.19 to 2.24

1.68

1.16 to 2.44

ACPA:

        

Unadjusted c

        

ACPA low positive

1.05

0.68 to 1.63

0.98

0.61 to 1.59

1.65

1.00 to 2.72

0.97

0.54 to 1.73

ACPA high positive

1.49

1.24 to 1.79

1.27

1.03 to 1.57

1.17

0.90 to 1.52

0.79

0.58 to 1.06

Age and sex adjusted c

        

ACPA low positive

1.16

0.75 to 1.81

1.19

0.73 to 1.93

2.52

1.52 to 4.18

1.99

1.10 to 3.61

ACPA high positive

1.41

1.17 to 1.69

1.29

1.04 to 1.59

1.45

1.11 to 1.90

1.37

1.00 to 1.89

Multivariate cb

        

ACPA low positive

1.39

0.89 to 2.16

1.44

0.89 to 2.36

2.21

1.31 to 3.72

1.78

0.96 to 3.28

ACPA high positive

1.32

1.08 to 1.61

1.24

0.99 to 1.57

1.25

0.93 to 1.69

1.22

0.86 to 1.73

  1. aRF negative was used as a reference group; badjusted for age at symptom onset, sex, baseline smoking status, year of inclusion in cohort and inflammatory marker; cACPA negative was used as a reference group. Inflammatory marker = C-reactive protein in NOAR, = erythrocyte sedimentation rate in EAC. ACPA, anti-citrullinated protein antibodies; CI, confidence interval; HR, hazard ratio; RF, rheumatoid factor. The bold and italic text indicates subtitles, hence why there are no values in the table next to them. It is therefore essential that they look different to the predictor variables and the result values themselves.