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Table 4 RF and ACPA positive versus single positive and both antibodies negative

From: Rheumatoid factor and anti-citrullinated protein antibody positivity, but not level, are associated with increased mortality in patients with rheumatoid arthritis: results from two large independent cohorts

 

NOAR

Leiden EAC

 

Total EIA population

2010 ACR/EULAR positive cohort

Total EIA population

2010 ACR/EULAR positive cohort

Model/predictor

HR

95% CI

HR

95% CI

HR

95% CI

HR

95% CI

Unadjusted

        

RF positive

1.11

0.83 to 1.49

1.10

0.79 to 1.53

1.88

1.29 to 2.74

1.53

0.99 to 2.36

ACPA positive

1.27

0.94 to 1.73

1.14

0.82 to 1.59

0.63

0.32 to 1.23

0.31

0.13 to 0.73

Both antibodies positive

1.51

1.23 to 1.85

1.29

1.02 to 1.64

1.59

1.21 to 2.09

1.12

0.80 to 1.57

Age and sex adjusted

        

RF positive

1.05

0.78 to 1.41

1.10

0.79 to 1.54

1.45

0.99 to 2.13

1.54

0.99 to 2.37

ACPA positive

1.40

1.03 to 1.91

1.42

1.02 to 1.99

0.96

0.48 to 1.90

0.71

0.30 to 1.68

Both antibodies positive

1.38

1.12 to 1.69

1.25

0.99 to 1.59

1.82

1.38 to 2.40

1.83

1.29 to 2.60

Multivariate a

        

RF positive

1.11

0.82 to 1.51

1.22

0.87 to 1.72

1. 48

0.99 to 2.21

1.47

0.94 to 2.30

ACPA positive

1.35

0.98 to 1.88

1.39

0.97 to 1.99

1.05

0.53 to 2.09

0.79

0.33 to 1.89

Both antibodies positive

1.35

1.09 to 1.68

1.31

1.01 to 1.69

1.57

1.15 to 2.14

1.59

1.08 to 2.32

  1. aAdjusted for age at symptom onset, sex, baseline smoking status, year of inclusion in cohort and inflammatory marker; both antibodies negative was used as reference group; inflammatory marker = C-reactive protein in NOAR, = erythrocyte sedimentation rate in EAC. ACPA, anti-citrullinated protein antibodies; CI, confidence interval; HR, hazard ratio; RF, rheumatoid factor. The bold and italic text indicates subtitles, hence why there are no values in the table next to them. It is therefore essential that they look different to the predictor variables and the result values themselves.