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Table 1 Mammalian sensory neurotransmitters and their receptors

From: The role of peripheral nerve fibers and their neurotransmitters in cartilage and bone physiology and pathophysiology

Neurotransmitters

Receptor (highest affinity)

Neuropeptide genes

Neuropeptide receptor genes

Substance P (SP)

Neurokinin (NK)1 receptor

Tachykinin (TAC) 1 or PPT-A or PPT-I

Tachykinin receptor (TACR) 1

Neurokinin A (NKA)

NK2 receptor

TAC1

TACR2

Alternatively spliced forms are neuropeptides (NP) K and NPγ.

Neurokinin B (NKB)

NK3 receptor

TAC3 or PPT-B or PPT-II

TACR3

Hemokinin 1 (HK1)

NK1 receptor, HK1 receptor?

TAC4 or PPT-C

TACR1

Alternatively spliced forms are endokinins (EK) A, B, C, D.

Alpha-calcitonin-gene-related peptide (βCGRP)

Calcitonin receptor-like receptor (CRLR)/receptor activity-modifying protein (RAMP-1)

CALCA

CALCR/RAMP1

Beta-calcitonin gene-related peptide (βCGRP)

CRLR/RAMP-1

CALCB

CALCR/RAMP1