Skip to main content

Table 1 Mammalian sensory neurotransmitters and their receptors

From: The role of peripheral nerve fibers and their neurotransmitters in cartilage and bone physiology and pathophysiology

Neurotransmitters Receptor (highest affinity) Neuropeptide genes Neuropeptide receptor genes
Substance P (SP) Neurokinin (NK)1 receptor Tachykinin (TAC) 1 or PPT-A or PPT-I Tachykinin receptor (TACR) 1
Neurokinin A (NKA) NK2 receptor TAC1 TACR2
Alternatively spliced forms are neuropeptides (NP) K and NPγ.
Neurokinin B (NKB) NK3 receptor TAC3 or PPT-B or PPT-II TACR3
Hemokinin 1 (HK1) NK1 receptor, HK1 receptor? TAC4 or PPT-C TACR1
Alternatively spliced forms are endokinins (EK) A, B, C, D.
Alpha-calcitonin-gene-related peptide (βCGRP) Calcitonin receptor-like receptor (CRLR)/receptor activity-modifying protein (RAMP-1) CALCA CALCR/RAMP1
Beta-calcitonin gene-related peptide (βCGRP) CRLR/RAMP-1 CALCB CALCR/RAMP1