Figure 1

Immunostaining of NTs and their receptors and T lymphocytes (CD3+) in temporal arteries of patients and controls. (A) Panels are representative examples of immunohistological images (x50 and x200) of temporal arteries from GCA patients (n = 22) compared to controls (n = 21). (B). Panels are measurements of significant NT immunostaining intensities. Results are shown as mean values and standard errors of the mean (SEM). (C) TrkB immunostaining in GCA patients with or without ischaemic complications. Immunoreactivity to TrkB in the media and intima of TAs in GCA patients with (n = 9) or without (n = 13) ischaemic complications. GCA, giant cell arteritis; NT, neurotrophin; TA, temporal artery; Trk, tropomyosin receptor kinase.