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Figure 3 | Arthritis Research & Therapy

Figure 3

From: Decreased histone deacetylase 4 is associated with human osteoarthritis cartilage degeneration by releasing histone deacetylase 4 inhibition of runt-related transcription factor-2 and increasing osteoarthritis-related genes: a novel mechanism of human osteoarthritis cartilage degeneration

Figure 3

Increased MMP-13, Ihh and type X collagen expression in OA cartilage. (A) Immunohistochemistry was performed to detect MMP-13, Ihh and type X collagen. The boxed regions indicate the magnified area shown at the right side. (B) Real-time PCR indicates that the level of MMP-13, Ihh and type X collagen increased in OA cartilages (n = 3) compared with normal cartilage (n = 3) (*P <0.05). (C, D) Western blotting showed expression of MMP-13, Ihh and type X collagen increased in OA samples compared with normal controls. Semi-quality by densitometry showed the mean concentration of MMP-13, Ihh and type X collagen in the cartilage of OA patients (n = 3) compared with the cartilage of normal controls (40- to 60-year-olds) (n = 3) (*P <0.05). MMP, matrix metalloprotease; OA, osteoarthritis; SD, standard deviation.

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Arthritis Research & Therapy

ISSN: 1478-6362

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