Table 2 Univariable logistic regression analysis of patients with BoPAP versus normal PAP and those with PAH versus BoPAP

Age, years

1.03 (1.00, 1.07)

1.04 (0.99, 1.08)

Gender, female versus male

0.69 (0.25, 1.89)

0.80 (0.27, 2.36)

WHO FC, III/IV versus I/II

2.27 (0.78, 6.56)

2.90 (1.04, 8.08)

<0.05

6-minute walk distance

1.00 (0.99, 1.00)

1.00 (1.00, 1.00)

SSc disease duration, years

0.99 (0.94, 1.04)

1.05 (1.00, 1.11)

SSc disease subtype

<0.05

dcSSc versus lcSSc

1.30 (0.59, 2.85)

0.35 (0.13, 0.93)

Overlap/mixed CTD versus lcSSc

1.23 (0.31, 4.81)

0.76 (0.17, 3.48)

Presence of telangiectasias

0.58 (0.27, 1.25)

4.13 (1.52, 11.26)

<0.01

Presence of peripheral edema

4.19 (1.41, 12.46)

0.93 (0.32, 2.67)

<0.05

FVC predicted

0.99 (0.97, 1.01)

1.01 (0.99, 1.04)

FVC % predicted /DLCO % predicted

1.24 (0.54, 2.82)

3.41 (1.36, 8.54)

<0.01

TLC % predicted

0.98 (0.96, 1.00)

1.01 (0.99, 1.04)

Presence of anti-centromere antibodies

0.78 (0.35, 1.77)

2.77 (1.12, 6.85)

<0.05

Log₁₀ NT-proBNP, pg/ml

2.65 (1.17, 5.98)

1.69 (0.71, 4.05)

<0.05

Serum urate, mg/100 ml

1.01 (0.76, 1.33)

1.73 (1.20, 2.48)

<0.01

Log₁₀ estimated GFR

0.54 (0.03, 9.44)

0.04 (0.00, 1.77)

Left atrium diameter, mm

1.22 (1.10, 1.35)

0.89 (0.80, 1.00)

<0.001

<0.05

Right atrium area, cm²

1.07 (1.00, 1.14)

1.07 (0.99, 1.17)

TAPSE, mm

1.03 (0.94, 1.12)

0.88 (0.80, 0.98)

<0.05

TR velocity, m/s

25.10 (6.07, 103.74)

3.15 (1.30, 7.67)

<0.0001

<0.05

Right axis deviation

2.35 (0.21, 26.74)

4.64 (0.55, 38.99)

PAWP, mmHg

1.39 (1.21, 1.61)

0.91 (0.79, 1.04)

<0.0001

TPG, mmHg

1.57 (1.33, 1.85)

1.72 (1.35, 2.19)

<0.0001

<0.0001

DWG, mmHg

1.10 (0.99, 1.21)

1.27 (1.12, 1.44)

<0.0005

PVR, dyn.sec/cm⁵

1.01 (1.01, 1.02)

1.03 (1.01, 1.04)

<0.0001

<0.0001