Skip to main content

Table 2 Univariable logistic regression analysis of patients with BoPAP versus normal PAP and those with PAH versus BoPAP

From: Borderline pulmonary arterial pressure in systemic sclerosis patients: a post-hoc analysis of the DETECT study

Variable Odds ratios (95% confidence interval) P-value
BoPAP versus normal mPAP PAH versus BoPAP BoPAP versus normal mPAP PAH versus BoPAP
Demographic and clinical parameters   
Age, years 1.03 (1.00, 1.07) 1.04 (0.99, 1.08)   
Gender, female versus male 0.69 (0.25, 1.89) 0.80 (0.27, 2.36)   
WHO FC, III/IV versus I/II 2.27 (0.78, 6.56) 2.90 (1.04, 8.08)   <0.05
6-minute walk distance 1.00 (0.99, 1.00) 1.00 (1.00, 1.00)   
SSc disease duration, years 0.99 (0.94, 1.04) 1.05 (1.00, 1.11)   
SSc disease subtype     <0.05
dcSSc versus lcSSc 1.30 (0.59, 2.85) 0.35 (0.13, 0.93)
Overlap/mixed CTD versus lcSSc 1.23 (0.31, 4.81) 0.76 (0.17, 3.48)
Presence of telangiectasias 0.58 (0.27, 1.25) 4.13 (1.52, 11.26)   <0.01
Presence of peripheral edema 4.19 (1.41, 12.46) 0.93 (0.32, 2.67) <0.05  
FVC predicted 0.99 (0.97, 1.01) 1.01 (0.99, 1.04)   
FVC % predicted /DLCO % predicted 1.24 (0.54, 2.82) 3.41 (1.36, 8.54)   <0.01
TLC % predicted 0.98 (0.96, 1.00) 1.01 (0.99, 1.04)   
Serum laboratory   
Presence of anti-centromere antibodies 0.78 (0.35, 1.77) 2.77 (1.12, 6.85)   <0.05
Log10 NT-proBNP, pg/ml 2.65 (1.17, 5.98) 1.69 (0.71, 4.05) <0.05  
Serum urate, mg/100 ml 1.01 (0.76, 1.33) 1.73 (1.20, 2.48)   <0.01
Log10 estimated GFR 0.54 (0.03, 9.44) 0.04 (0.00, 1.77)   
Echocardiography   
Left atrium diameter, mm 1.22 (1.10, 1.35) 0.89 (0.80, 1.00) <0.001 <0.05
Right atrium area, cm2 1.07 (1.00, 1.14) 1.07 (0.99, 1.17)   
TAPSE, mm 1.03 (0.94, 1.12) 0.88 (0.80, 0.98)   <0.05
TR velocity, m/s 25.10 (6.07, 103.74) 3.15 (1.30, 7.67) <0.0001 <0.05
Electrocardiography   
Right axis deviation 2.35 (0.21, 26.74) 4.64 (0.55, 38.99)   
Right heart catheterization   
PAWP, mmHg 1.39 (1.21, 1.61) 0.91 (0.79, 1.04) <0.0001  
TPG, mmHg 1.57 (1.33, 1.85) 1.72 (1.35, 2.19) <0.0001 <0.0001
DWG, mmHg 1.10 (0.99, 1.21) 1.27 (1.12, 1.44)   <0.0005
PVR, dyn.sec/cm5 1.01 (1.01, 1.02) 1.03 (1.01, 1.04) <0.0001 <0.0001
  1. BoPAP, borderline pulmonary arterial pressure; CTD, connective tissue disease; dcSSc, diffuse cutaneous SSc; DLCO, diffusing capacity of carbon monoxide; DWG, diastolic wedge gradient; FVC, forced vital capacity; GFR, glomerular filtration rate; lcSSc, limited cutaneous SSc; NT-proBNP, N-terminal pro-brain natriuretic peptide; PAH, pulmonary arterial hypertension; PAWP, pulmonary artery wedge pressure; PVR, pulmonary vascular resistance; SSc, systemic sclerosis; TAPSE, tricuspid annular plane systolic excursion; TLC, total lung capacity; TPG, transpulmonary gradient; TR, tricuspid regurgitation; WHO FC, World Health Organization functional class.