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Table 4 Analysis for association of gout risk with lipid and apo B-associated traits in non-tophaceous gout (left) and gout excluding participants taking fenofibrate and statins (right)

From: The relationship of apolipoprotein B and very low density lipoprotein triglyceride with hyperuricemia and gout

 

HU vs non-tophaceous gout

HU vs lipid-lowering excluded gout

Adjusted OR [95% CI]

P

Adjusted OR [95% CI]

P

Total Tg (mmol/L)

    

Europeans

1.11 [0.55-2.26]

0.77

1.30 [0.367-2.51]

0.44

Polynesians

0.95 [0.50-1.80]

0.88

1.16 [0.68-1.96]

0.59

Combined

1.04 [0.72-1.50]

0.82

1.24 [0.86-1.78]

0.25

Total FPLC Tg (mmol/L)

    

Europeans

3.64 [0.96-13.82]

0.068

7.41 [1.42-38.56]

0.017

Polynesians

1.05 [0.29-3.77]

0.94

1.58 [0.62-4.05]

0.34

Combined

1.78 [0.91-3.48]

0.091

2.37 [1.17-4.83]

0.017

VLDL Tg (mmol/L)

    

Europeans

5.10 [0.97-26.81]

0.054

26.15 [2.48-276.04]

0.007

Polynesians

1.72 [0.37-7.96]

0.49

3.18 [0.84-12.05]

0.089

Combined

2.78 [1.13-6.79]

0.025

4.77 [1.76-12.96]

0.002

Total apo B ( μmol/L)

    

Europeans

4.32 [0.86-21.69]

0.075

3.17 [0.71-14.09]

0.13

Polynesians

158.22 [1.95-1286.5]

0.024

7.23 [0.28-189.08]

0.24

Combined

11.58 [2.62-51.15]

0.001

4.32 [1.17-15.93]

0.028

VLDL apo B (0.1μmol/L)

    

Europeans

1.99 [0.67-5.91]

0.22

1.85 [0.52-6.57]

0.34

Polynesians

0.39 [0.04-3.82]

0.42

1.80 [0.50-6.49]

0.37

Combined

1.32 [0.63-2.77]

0.46

1.64 [0.74-3.63]

0.23

VLDL Tg:VLDL apo B

    

Europeans

1.06 [0.93-1.21]

0.39

1.05 [0.92-1.20]

0.43

Polynesians

1.48 [1.02-2.15]

0.041

1.11 [1.00-1.24]

0.060

Combined

1.07 [1.01-1.15]

0.029

1.07 [1.00-1.14]

0.042

  1. Adjusted for age, BMI, type 2 diabetes, SSB intake (drinks/day), alcohol intake (drinks/week), eGFR, hypertension and prescription of lipid-lowering medication for the non-tophaceous analysis. The Polynesian data are also adjusted by number of self-reported Polynesian grandparents. The combined analysis was additionally adjusted by ancestral group. HU: hyperuricaemia; OR: odds ratio; CI: confidence interval; Tg: triglyceride; FPLC: fast protein liquid chromatography; VLDL: very low-density lipoprotein; apo B: apolipoprotein B; BMI, body mass index; SSB: sugar-sweetened beverage; eGRF: estimated glomerular filtration rate.