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Table 4 Analysis for association of gout risk with lipid and apo B-associated traits in non-tophaceous gout (left) and gout excluding participants taking fenofibrate and statins (right)

From: The relationship of apolipoprotein B and very low density lipoprotein triglyceride with hyperuricemia and gout

  HU vs non-tophaceous gout HU vs lipid-lowering excluded gout
Adjusted OR [95% CI] P Adjusted OR [95% CI] P
Total Tg (mmol/L)     
Europeans 1.11 [0.55-2.26] 0.77 1.30 [0.367-2.51] 0.44
Polynesians 0.95 [0.50-1.80] 0.88 1.16 [0.68-1.96] 0.59
Combined 1.04 [0.72-1.50] 0.82 1.24 [0.86-1.78] 0.25
Total FPLC Tg (mmol/L)     
Europeans 3.64 [0.96-13.82] 0.068 7.41 [1.42-38.56] 0.017
Polynesians 1.05 [0.29-3.77] 0.94 1.58 [0.62-4.05] 0.34
Combined 1.78 [0.91-3.48] 0.091 2.37 [1.17-4.83] 0.017
VLDL Tg (mmol/L)     
Europeans 5.10 [0.97-26.81] 0.054 26.15 [2.48-276.04] 0.007
Polynesians 1.72 [0.37-7.96] 0.49 3.18 [0.84-12.05] 0.089
Combined 2.78 [1.13-6.79] 0.025 4.77 [1.76-12.96] 0.002
Total apo B ( μmol/L)     
Europeans 4.32 [0.86-21.69] 0.075 3.17 [0.71-14.09] 0.13
Polynesians 158.22 [1.95-1286.5] 0.024 7.23 [0.28-189.08] 0.24
Combined 11.58 [2.62-51.15] 0.001 4.32 [1.17-15.93] 0.028
VLDL apo B (0.1μmol/L)     
Europeans 1.99 [0.67-5.91] 0.22 1.85 [0.52-6.57] 0.34
Polynesians 0.39 [0.04-3.82] 0.42 1.80 [0.50-6.49] 0.37
Combined 1.32 [0.63-2.77] 0.46 1.64 [0.74-3.63] 0.23
VLDL Tg:VLDL apo B     
Europeans 1.06 [0.93-1.21] 0.39 1.05 [0.92-1.20] 0.43
Polynesians 1.48 [1.02-2.15] 0.041 1.11 [1.00-1.24] 0.060
Combined 1.07 [1.01-1.15] 0.029 1.07 [1.00-1.14] 0.042
  1. Adjusted for age, BMI, type 2 diabetes, SSB intake (drinks/day), alcohol intake (drinks/week), eGFR, hypertension and prescription of lipid-lowering medication for the non-tophaceous analysis. The Polynesian data are also adjusted by number of self-reported Polynesian grandparents. The combined analysis was additionally adjusted by ancestral group. HU: hyperuricaemia; OR: odds ratio; CI: confidence interval; Tg: triglyceride; FPLC: fast protein liquid chromatography; VLDL: very low-density lipoprotein; apo B: apolipoprotein B; BMI, body mass index; SSB: sugar-sweetened beverage; eGRF: estimated glomerular filtration rate.