Figure 6

Epigallocatechin 3-gallate treatment results in a chondroprotective gene expression profile. Relative gene expression levels of catabolic enzymes, inflammatory cytokines and the matrix metalloproteinase (MMP) regulator CBP/p300-interacting transactivator with ED-rich tail 2 (Cited2) in the articular cartilage of mice that underwent sham operations or surgical destabilization of the medial meniscus (DMM) that were treated with vehicle or epigallocatechin 3-gallate (EGCG) at 4 weeks following surgery (*P < 0.05 by analysis of variance; n = 5/group). Adamts5, A disintegrin and metalloproteinase with thrombospondin motifs 5; Il1b, interleukin 1 beta; Tnfa, Tumor necrosis factor alpha.