Effects of lacosamide after monosodium iodoacetate injection. These graphs depict the effects of lacosamide (LCM) on paw withdrawal threshold after mechanical punctate stimulation (a), paw withdrawal frequency after cooling stimulation (b) and hind limb weight-bearing (c) after monosodium iodoacetate (MIA) injection. LCM at 30 mg/kg reversed the mechanical hypersensitive response. LCM at both doses reversed the hypersensitivity to cooling stimulation but had no effect on hind limb weight-bearing. * denotes significant effect (P < 0.05 by Kruskal-Wallis test with Dunn’s post hoc test) comparing LCM effect with vehicle-treated animals. Data are from five animals per group. Values are mean ± SEM.