Skip to main content

Table 4 Histopathological evaluation criteria a

From: Pirfenidone gel in patients with localized scleroderma: a phase II study

  Epidermal atrophy Dermal infiltration Adipose tissue infiltration Papillary dermis fibrosis Reticular dermis fibrosis Adipose tissue fibrosis Adnexal atrophy
  Basal Final Basal Final Basal Final Basal Final Basal Final Basal b Final c Basal Final
Absence 1 4 0 0 4 3 1 3 1 4 2 0 1 1
Light 1 4 4 8 3 9 6 3 4 2 3 3 4 3
Moderate 4 1 5 3 5 0 2 3 1 6 2 1 3 3
Severe 6 3 3 1 0 0 3 3 6 0 4 5 4 5
Mean (SD) 2.25 (0.96) 1.25 (1.21) 1.92 (0.79) 1.42 (0.67) 1.08 (0.90) 0.75 (0.45) 1.58 (1.0) 1.5 (1.17) 2 (1.13) 1.17 (0.94) 1.72 (1.19) 2.22 (0.97) 1.83 (1.03) 2 (1.04)
P-valued   0.010   0.034   0.305   0.705   0.039   0.276   0.581
  1. aThe microscopic findings showed statistically significant changes in epidermal atrophy, dermal infiltration and reticular dermis fibrosis. bNonevaluable case. cThree nonevaluable cases. dWilcoxon rank-sum test. SD, Standard deviation.