Figure 1

Genetic variants in IL-6 (A), IL-10 (B), C5-TRAF1 (C) and FCRL3 (D) in relation to radiographic joint damage progression. Presented are the yearly radiographic progression rates per individual cohort and the meta-analyses evaluating the six cohorts combined, consisting in total of 2,493 patients and 5,895 sets of radiographs. None of the studied genetic variants were significantly associated with radiographic progression, neither in the individual cohorts nor in meta-analysis. Rs1800795 (IL-6) I² 0.0%, P 0.67; P fixed effect 0.72, P random effect 0.72; rs1800896 (IL-10) I² 20.8%, P 0.28; P fixed effect 0.93, P random effect 0.89; rs2900180 (C5-TRAF1) I² 28.7%, P 0.22; P fixed effect 0.22, P random effect 0.63; rs7528684 (FCRL3) I² 26.0%, P 0.24; P fixed effect 0.83, P random effect 0.73.