Figure 3

LD plots of the C5-TRAF1 region. (A) Total region in hapmap CEU patients and (B) fine-mapped in Leiden EAC. The colors reflect de D’ between the SNPs. Coordinates relate to NCBI36 hg18 release 2006. (C) Results of the multivariate normal regression analysis for 424 variants in the C5-TRAF1 region in the ACPA-negative patients of the EAC. Rs2900180 is the initially studied variant (green), rs7021880 is the variant with the lowest P-value (red) and rs10818488 is the variant we previously studied in relation to radiographic progression (yellow) and did not associate with radiographic progression in the total population [29]. Also in the current study, rs10818488 did not pass the cut-off for multiple testing correction in the ACPA-negative patients. Using the Bonferroni correction (considering 424 variants studied) the cut-off for statistical significance was set at 1.18 × 10⁻⁴ as represented by the horizontal line. ACPA, anti-citrullinated peptide antibodies; EAC, Early Arthritis Clinic; LD, linkage disequilibrium.