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Table 1 Descriptions for cartilage degeneration scoring

From: Overexpression of cystatin C in synovium does not reduce synovitis or cartilage degradation in established osteoarthritis

Score

Description

0

No degeneration

1

Minimal degeneration, within the zone 3-10% of the matrix appears nonviable as a result of significant chondrocyte loss (greater than 50% of normal cell density lost in affected areas). Proteoglycan loss is usually present in these areas of cell loss and collagen matrix loss may be present

2

Mild degeneration, within the zone 11-25% of the matrix appears nonviable as a result of significant chondrocyte loss (greater than 50% of normal cell density lost in affected areas). Proteoglycan loss is usually present in these areas of cell loss and collagen matrix loss may be present

3

Moderate degeneration, within the zone 26-50% of the matrix appears nonviable as a result of significant chondrocyte loss (greater than 50% of normal cell density lost in affected areas). Proteoglycan loss is usually present in these areas of cell loss and collagen matrix loss may be present

4

Marked degeneration, within the zone 51-75% of the matrix appears nonviable as a result of significant chondrocyte loss (greater than 50% of normal cell density lost in affected areas). Proteoglycan loss is usually present in these areas of cell loss and collagen matrix loss may be present

5

Severe degeneration, within the zone 76-100% of the matrix appears nonviable as a result of significant chondrocyte loss (greater than 50% of normal cell density lost in affected areas). Proteoglycan loss is usually present in these areas of cell loss and collagen matrix loss may be present