Application of the 2012 Systemic Lupus International Collaborating Clinics classification criteria to patients in a regional Swedish systemic lupus erythematosus register

Table 1 Characteristics of the 243 included patients with confirmed systemic lupus erythematosus ^a

Characteristics	All confirmed SLE cases ( N = 243)		ACR-82 ( n = 197)		Fries only ( n = 46)		ACR-82 vs. Fries P -values
Characteristics	Mean	(Range)	Mean	(Range)	Mean	(Range)
Fulfilled ACR-82 criteria, n	4.6	(3 to 9)	5.0	(4 to 9)	3.0	(3 to 3)	<0.0001^b
SLICC/ACR damage index	1.6	(0 to 9)	1.7	(0 to 9)	1.2	(0 to 7)	0.25^b
Disease duration, yr	15.1	(0 to 52)	15.6	(0 to 52)	12.9	(1 to 40)	0.18^b
Age, yr	52.8	(20 to 92)	52.2	(20 to 92)	55.6	(20 to 82)	0.20^b
Female sex, %	87.7		87.5		89.1		0.74^b
Caucasians, %	92.2		91.4		95.7		0.33^b
*Clinical manifestations (%)*
Acute cutaneous lupus	65.8		71.6		41.3		<0.0001^c
Chronic cutaneous lupus	15.2		17.8		4.3		0.023^c
Photosensitivity	50.6		56.3		26.1		0.0002^c
Nonscarring alopecia	21.4		22.3		17.4		0.46^c
Oral ulcers	11.1		12.7		4.3		0.11^c
Arthritis	75.7		76.1		73.9		0.75^c
Pleuritis	37.9		39.1		32.6		0.41^c
Pericarditis	14.8		15.2		13.0		0.71^c
Renal disorder	23.9		28.9		2.2		<0.0001^c
Biopsy-proven lupus nephritis	19.8		23.9		2.2		0.0009^c
Neurologic disorder (ACR-82)	4.9		5.6		2.2		0.34^c
Neurologic disorder (SLICC-12)	10.7		12.7		2.2		0.038^c
Haemolytic anaemia	4.9		6.1		0		0.086^c
Leukopenia	29.2		33.0		13.0		0.0074^c
Lymphopenia	29.2		34.0		8.7		0.0007^c
Thrombocytopenia	11.5		12.7		6.5		0.24^c
*Immunologic criteria (%)*
Antinuclear antibody	98.8		98.5		100.0		0.40^c
Anti-dsDNA	45.3		53.3		10.9		<0.0001^c
Anti-Sm	8.2		9.1		4.3		0.29^c
Lupus anticoagulant^d	36.3		34.3		43.6		0.097^c
Anti-cardiolipin^e	28.5		30.7		19.5		0.23^c
Anti-β₂-glycoprotein-1^f	29.2		30.0		25.9		0.80^c
Low complement	47.3		51.3		30.4		0.011^c
Direct Coombs test^g	51.3		58.1		29.6		0.25^c

^aACR-82, American College of Rheumatology 1982 criteria; Anti-dsDNA, Antibodies to double-stranded DNA; Anti-Sm, Anti-Smith antibody; Fries, Fries and Holman’s diagnostic principle [7]; SLE, Systemic lupus erythematosus; SLICC-12, 2012 Systemic Lupus International Collaborating Clinics criteria. ^b P-values based on Mann–Whitney U test. ^c P-values based on χ² test. Criteria were tested on any occasion in ^d182 of 243 patients, ^e207 of 243 patients, ^f137 of 243 patients and ^g113 of 243 patients.

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