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Table 3 Sensitivity, specificity and positive and negative predictive values for each separate classification ground, as well as for some combinations a

From: Application of the 2012 Systemic Lupus International Collaborating Clinics classification criteria to patients in a regional Swedish systemic lupus erythematosus register

 

Sensitivity

Specificity

PPV

NPV

Fries

0.98 (0.95 to 0.99)

0.81 (0.68 to 0.90)

0.84 (0.75 to 0.94)

0.94 (0.86 to 1.00)

ACR-82

0.80 (0.75 to 0.85)

1 (0.91 to 1.00)

1 (0.93 to 1.00)

0.81 (0.71 to 0.91)

ACR-97

0.90 (0.85 to 0.93)

0.92 (0.81 to 0.98)

0.93 (0.84 to 1.00)

0.87 (0.78 to 0.97)

SLICC-12

0.94 (0.90 to 0.96)

0.74 (0.60 to 0.84)

0.79 (0.70 to 0.89)

0.92 (0.83 to 1.00)

SLICC-12:2

0.89 (0.84 to 0.92)

0.77 (0.64 to 0.87)

0.81 (0.71 to 0.91)

0.87 (0.76 to 0.98)

Fries and/or ACR-82

0.99 (0.97 to 1.00)

0.81 (0.68 to 0.90)

0.85 (0.75 to 0.94)

0.96 (0.87 to 1.00)

Fries and/or ACR-97

1 (0.97 to 1.00)

0.81 (0.68 to 0.90)

0.85 (0.75 to 0.94)

0.96 (0.87 to 1.00)

Fries and/or SLICC-12

0.99 (0.97 to 1.00)

0.68 (0.54 to 0.79)

0.77 (0.67 to 0.86)

0.99 (0.91 to 1.00)

ACR-82 and/or SLICC-12

0.96 (0.92 to 0.98)

0.74 (0.60 to 0.84)

0.80 (0.70 to 0.89)

0.95 (0.86 to 1.00)

ACR-82 and/or SLICC-12:2

0.93 (0.90 to 0.96)

0.77 (0.64 to 0.87)

0.82 (0.72 to 0.91)

0.92 (0.82 to 1.00)

At least one of Fries, ACR-82 or SLICC-12

1 (0.98 to 1.00)

0.68 (0.54 to 0.79)

0.77 (0.67 to 0.87)

1 (0.92 to 1.00)

At least one of Fries, ACR-82 or SLICC-12:2

1 (0.98 to 1.00)

0.72 (0.58 to 0.82)

0.79 (0.70 to 0.89)

1 (0.92 to 1.00)

(Fries + ACR-82) and/or (Fries + SLICC-12)

0.94 (0.90 to 0.96)

0.87 (0.75 to 0.94)

0.88 (0.79 to 0.97)

0.90 (0.82 to 0.99)

  1. aACR-82, American College of Rheumatology 1982 criteria; ACR-97, American College of Rheumatology 1997 criteria; Fries, Fries and Holman’s diagnostic principle [7]; NPV, Negative predictive value; PPV, Positive predictive value; SLICC-12, 2012 Systemic Lupus International Collaborating Clinics criteria; SLICC-12:2, SLICC-12 criteria with a requirement for involvement of at least two organ systems for SLE diagnosis. Data are presented with 95% confidence intervals in parentheses.