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Table 1 Patient baseline demographics and clinical characteristics a

From: Peripheral blood CD4+CD25+CD127low regulatory T cells are significantly increased by tocilizumab treatment in patients with rheumatoid arthritis: increase in regulatory T cells correlates with clinical response

Patient characteristics, N= 39

Mean ± SD or n (%)

Median (IQR)

Age, yr

54.8 ± 13.3

56 (44 to 63)

Female, n (%)

35 (89.7)

Disease duration, yr

4.7 ± 3.3

4.5 (1.7 to 8.0)

SJC (range, 0 to 28)

5.8 ± 3.8

5 (3 to 7)

TJC (range, 0 to 28)

5.0 ± 3.5

4 (3 to 6)

Pt-VAS (score/100 mm)

46.2 ± 24.5

45 (30 to 63)

D-VAS (score/100 mm)

42.3 ± 16.7

39 (32 to 54)

CDAI score

19.6 ± 9.3

17.5 (12.0 to 25.2)

SDAI score

21.1 ± 9.9

19.8 (13.4 to 26.9)

HAQ-DI score

1.0 ± 0.7

1 (0.5 to 1.5)

CRP, mg/dl

1.4 ± 1.6

0.7 (0.2 to 2.2)

ESR, mm/h

48.1 ± 32.0

46 (19 to 68)

MMP-3, ng/ml

158.5 ± 147.7

100.2 (60.0 to 221.0)

RF-positive, n (%)

33 (84.6)

ACPA-positive, n (%)

33 (84.6)

Concomitant methotrexate, n (%), dose,b mg/wk

12 (30.8), 8.0 ± 1.2

–, 8.0 (7.6 to 8.0)

Concomitant glucocorticoid, n (%), dose,b mg/day

10 (25.6), 5.1 ± 2.8

–, 5 (3 to 5)

  1. aACPA, Anticitrullinated protein antibody; CDAI, Clinical Disease Activity Index; CRP, C-reactive protein; D-VAS, Doctor’s visual analogue scale; ESR, Erythrocyte sedimentation rate; HAQ-DI, Health Assessment Questionnaire Disability Index; MMP-3, Matrix metalloproteinase-3; Pt-VAS, Patient’s visual analogue scale; RF, Rheumatoid factor; SDAI, Simplified Disease Activity Index; SJC, Swollen joint count; TJC, Tender joint count. bMean ± standard deviation (SD) and median (interquartile range (IQR)) among patients receiving drugs.