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Table 2 Changes in proportions of subsets and surface markers of T cells during tocilizumab treatment

From: Peripheral blood CD4+CD25+CD127low regulatory T cells are significantly increased by tocilizumab treatment in patients with rheumatoid arthritis: increase in regulatory T cells correlates with clinical response

Subsets and surface markers Median (interquartile range) Baseline vs. week 52
  Baseline Week 24 Week 52 P- value
CD4+ T cells/lymphocytes 53.6 (47.3 to 59.4) 53.4 (47.3 to 58.4) 55.3 (49.5 to 60.5) 0.345
Naïve CD4+ T cells/CD4+ T cells 61.8 (57.7 to 69.3) 59.1 (53.7 to 62.2) 59.1 (51.8 to 61.8) 0.019*
Memory CD4+ T cells/CD4+ T cells 30.7 (30.7 to 42.3) 40.9 (37.8 to 46.3) 40.9 (38.2 to 48.2) 0.010*
HLA-DR+CD4+ T cells/CD4+ T cells 3.2 (2.7 to 4.1) 3.1 (2.6 to 3.9) 2.6 (2 to 3.1) 0.005*
CD38+CD4+ T cells/CD4+ T cells 32.4 (26.3 to 38.5) 32.4 (28.4 to 39.4) 32.6 (29.3 to 40.1) 0.212
CD69+CD4+ T cells/CD4+ T cells 0.1 (0 to 0.1) 0.1 (0 to 0.2) 0.1 (0.1 to 0.3) 0.016*
CD8+ T cells/lymphocytes 32.4 (28.4 to 38.1) 30.8 (26.9 to 37.1) 29.1 (26.4 to 33.1) 0.052
Naïve CD8+ T cells/CD8+ T cells 60.8 (57.7 to 64.3) 62.1 (59.5 to 67.5) 62.7 (59.5 to 67.5) 0.087
Memory CD8+ T cells/CD8+ T cells 39.2 (35.7 to 42.3) 37.9 (33.9 to 41.5) 37.3 (32.5 to 40.5) 0.087
HLA-DR+CD8+ T cells/CD8+ T cells 16.4 (13.4 to 19.4) 18.3 (14.3 to 19.4) 19.4 (17.3 to 21.4) 0.005*
CD38+CD8+ T cells/CD8+ T cells 25.2 (15.9 to 36.7) 26.1 (19.3 to 31.4) 24.5 (19.4 to 30) 0.727
CD69+CD8+ T cells/CD8+ T cells 1.3 (0.5 to 2.1) 1.3 (0.9 to 2.1) 0.9 (0.3 to 1.3) 0.057
Treg/CD4+ T cells 3.6 (2.2 to 4.3) 4.2 (2.6 to 5.2) 5.6 (4.5 to 7.1) <0.001*
Naïve Treg/Treg cells 52.8 (44.0 to 59.0) 47.7 (42.6 to 54.9) 49.6 (46.5 to 55.7) 0.242
Memory Treg/Treg cells 47.2 (41 to 56.1) 52.3 (45.1 to 57.4) 50.4 (44.3 to 53.5) 0.242
HLA-DR+ Treg/ Treg cells 14 (11.7 to 17.7) 16.8 (14.3 to 20.3) 18.4 (15.4 to 19.4) <0.001*
TH1/CD4+ T cells 19 (14.8 to 20.8) 17.4 (15.3 to 19.3) 20.7 (15.9 to 22.9) 0.095
HLA-DR+ TH1/TH1 cells 4.5 (3.4 to 5.7) 4.5 (3.4 to 5.7) 3.5 (2.2 to 5.6) 0.119
TH2/CD4+ T cells 46.8 (37.7 to 54.3) 51.8 (42.5 to 58.7) 43.3 (34.6 to 49.1) 0.179
HLA-DR+ TH2/TH2 cells 2.0 (1.2 to 3.1) 2.3 (1.9 to 2.9) 2.2 (1.8 to 2.9) 0.174
TH17/CD4+ T cells 2.0 (0.78 to 3.2) 2.0 (1.4 to 3.2) 2.0 (1.5 to 3.6) 0.342
HLA-DR+ TH17/TH17 cells 4.0 (3.4 to 4.4) 3.6 (3.1 to 4.1) 3.9 (3.3 to 4.2) 0.323
  1. *Significant differences determined using Wilcoxon’s matched-pairs signed-rank test.
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