Peripheral blood CD4+CD25+CD127low regulatory T cells are significantly increased by tocilizumab treatment in patients with rheumatoid arthritis: increase in regulatory T cells correlates with clinical response

Kikuchi, Jun; Hashizume, Misato; Kaneko, Yuko; Yoshimoto, Keiko; Nishina, Naoshi; Takeuchi, Tsutomu

doi:10.1186/s13075-015-0526-4

Table 4 Correlations of changes in disease activities with changes in peripheral cell subsets and surface markers after 52 weeks of treatment with tocilizumab ^a

From: Peripheral blood CD4⁺CD25⁺CD127^low regulatory T cells are significantly increased by tocilizumab treatment in patients with rheumatoid arthritis: increase in regulatory T cells correlates with clinical response

	∆CDAI		∆SDAI
Subset	P -value	Spearman’s ρ	P -value	Spearman’s ρ
ΔCD4⁺ T cells/lymphocytes	0.273	0.180	0.342	0.156
ΔNaïve CD4⁺ T cells/CD4⁺ T cells	0.653	−0.074	0.481	−0.116
ΔMemory CD4⁺ T cells/CD4⁺ T cells	0.653	0.074	0.481	0.116
ΔHLA-DR⁺ CD4⁺ T cells/CD4⁺ T cells	0.829	−0.036	0.710	−0.061
ΔCD38⁺ CD4⁺ T cells/CD4⁺ T cells	0.231	−0.196	0.089	−0.276
ΔCD69⁺ CD4⁺ T cells/CD4⁺ T cells	0.746	−0.054	0.476	−0.118
ΔCD8⁺ T cells/lymphocytes	0.698	−0.064	0.294	−0.172
ΔNaïve CD8⁺ T cells/CD8⁺ T cells	0.555	0.097	0.256	0.186
ΔMemory CD8⁺ T cells/CD8⁺ T cells	0.555	−0.097	0.256	−0.186
ΔHLA-DR⁺ CD8⁺ T cells/CD8⁺ T cells	0.566	−0.095	0.955	0.009
ΔCD38⁺ CD8⁺ T cells/CD8⁺ T cells	0.026*	−0.355	0.036*	−0.337
ΔCD69⁺ CD8⁺ T cells/CD8⁺ T cells	0.686	−0.067	0.357	−0.152
ΔT_reg/CD4⁺ T cells	0.031*	−0.346	0.033*	−0.342
ΔNaïve T_reg/T_reg	0.930	0.015	0.612	0.084
ΔMemory T_reg/T_reg	0.924	−0.016	0.606	−0.085
ΔHLA-DR⁺ T_reg/T_reg	0.270	−0.181	0.279	−0.178
ΔT_H1/CD4⁺ T cells	0.847	−0.032	0.915	−0.018
ΔHLA-DR⁺ T_H1/ T_H1	0.969	0.007	0.732	0.057
ΔT_H2/CD4⁺ T cells	0.354	0.153	0.312	0.166
ΔHLA-DR⁺ T_H2/ T_H2	0.291	−0.173	0.152	−0.234
ΔT_H17/CD4⁺ T cells	0.593	−0.088	0.442	−0.127
ΔHLA-DR⁺ T_H17/ T_H17	0.366	−0.149	0.229	−0.197
ΔB cells/lymphocytes	0.958	−0.009	0.709	−0.062
ΔCD80⁺ B cells/B cells	0.740	0.055	0.546	0.100
ΔCD86⁺ B cells/B cells	0.210	0.206	0.065	0.299
ΔHLA-DR⁺ B cells/B cells	0.838	−0.034	0.841	−0.033
ΔNaïve B cells/B cells	0.291	−0.174	0.306	−0.168
ΔMemory B cells/B cells	0.291	0.174	0.306	−0.168
ΔNK cells/lymphocytes	0.559	0.097	0.506	0.110
ΔCD80⁺ CD14⁺ monocytes/CD14⁺ monocytes	0.645	−0.076	0.699	−0.064
ΔCD86⁺ CD14⁺ monocytes/CD14⁺ monocytes	0.440	0.127	0.776	0.047
ΔHLA-DR⁺ CD14⁺ monocytes/CD14⁺ monocytes	0.415	−0.134	0.138	−0.242
ΔCD69⁺ CD14⁺ monocytes/CD14⁺ monocytes	0.430	−0.130	0.258	−0.186
ΔCD16⁺CD14⁺ monocytes/CD14⁺ monocytes	0.120	−0.253	0.203	−0.208
ΔCD16⁻CD14⁺ monocytes/CD14⁺ monocytes	0.121	0.253	0.204	0.208

^aCDAI, Clinical Disease Activity Index; HLA, Human leukocyte antigen; NK, Natural killer; SDAI, Simplified Disease Activity Index; T_H, Helper T cell; T_reg, Regulatory T cell. *Significant correlation using Spearman’s rank correlation coefficient.

Back to article page

ISSN: 1478-6362

Contact us

General enquiries: journalsubmissions@springernature.com

Arthritis Research & Therapy

Contact us