Skip to main content

Table 4 Correlations of changes in disease activities with changes in peripheral cell subsets and surface markers after 52 weeks of treatment with tocilizumab a

From: Peripheral blood CD4+CD25+CD127low regulatory T cells are significantly increased by tocilizumab treatment in patients with rheumatoid arthritis: increase in regulatory T cells correlates with clinical response

  ∆CDAI ∆SDAI
Subset P -value Spearman’s ρ P -value Spearman’s ρ
ΔCD4+ T cells/lymphocytes 0.273 0.180 0.342 0.156
ΔNaïve CD4+ T cells/CD4+ T cells 0.653 −0.074 0.481 −0.116
ΔMemory CD4+ T cells/CD4+ T cells 0.653 0.074 0.481 0.116
ΔHLA-DR+ CD4+ T cells/CD4+ T cells 0.829 −0.036 0.710 −0.061
ΔCD38+ CD4+ T cells/CD4+ T cells 0.231 −0.196 0.089 −0.276
ΔCD69+ CD4+ T cells/CD4+ T cells 0.746 −0.054 0.476 −0.118
ΔCD8+ T cells/lymphocytes 0.698 −0.064 0.294 −0.172
ΔNaïve CD8+ T cells/CD8+ T cells 0.555 0.097 0.256 0.186
ΔMemory CD8+ T cells/CD8+ T cells 0.555 −0.097 0.256 −0.186
ΔHLA-DR+ CD8+ T cells/CD8+ T cells 0.566 −0.095 0.955 0.009
ΔCD38+ CD8+ T cells/CD8+ T cells 0.026* −0.355 0.036* −0.337
ΔCD69+ CD8+ T cells/CD8+ T cells 0.686 −0.067 0.357 −0.152
ΔTreg/CD4+ T cells 0.031* −0.346 0.033* −0.342
ΔNaïve Treg/Treg 0.930 0.015 0.612 0.084
ΔMemory Treg/Treg 0.924 −0.016 0.606 −0.085
ΔHLA-DR+ Treg/Treg 0.270 −0.181 0.279 −0.178
ΔTH1/CD4+ T cells 0.847 −0.032 0.915 −0.018
ΔHLA-DR+ TH1/ TH1 0.969 0.007 0.732 0.057
ΔTH2/CD4+ T cells 0.354 0.153 0.312 0.166
ΔHLA-DR+ TH2/ TH2 0.291 −0.173 0.152 −0.234
ΔTH17/CD4+ T cells 0.593 −0.088 0.442 −0.127
ΔHLA-DR+ TH17/ TH17 0.366 −0.149 0.229 −0.197
ΔB cells/lymphocytes 0.958 −0.009 0.709 −0.062
ΔCD80+ B cells/B cells 0.740 0.055 0.546 0.100
ΔCD86+ B cells/B cells 0.210 0.206 0.065 0.299
ΔHLA-DR+ B cells/B cells 0.838 −0.034 0.841 −0.033
ΔNaïve B cells/B cells 0.291 −0.174 0.306 −0.168
ΔMemory B cells/B cells 0.291 0.174 0.306 −0.168
ΔNK cells/lymphocytes 0.559 0.097 0.506 0.110
ΔCD80+ CD14+ monocytes/CD14+ monocytes 0.645 −0.076 0.699 −0.064
ΔCD86+ CD14+ monocytes/CD14+ monocytes 0.440 0.127 0.776 0.047
ΔHLA-DR+ CD14+ monocytes/CD14+ monocytes 0.415 −0.134 0.138 −0.242
ΔCD69+ CD14+ monocytes/CD14+ monocytes 0.430 −0.130 0.258 −0.186
ΔCD16+CD14+ monocytes/CD14+ monocytes 0.120 −0.253 0.203 −0.208
ΔCD16CD14+ monocytes/CD14+ monocytes 0.121 0.253 0.204 0.208
  1. aCDAI, Clinical Disease Activity Index; HLA, Human leukocyte antigen; NK, Natural killer; SDAI, Simplified Disease Activity Index; TH, Helper T cell; Treg, Regulatory T cell. *Significant correlation using Spearman’s rank correlation coefficient.
\