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Figure 2 | Arthritis Research & Therapy

Figure 2

From: Non-canonical NF-κB signaling in rheumatoid arthritis: Dr Jekyll and Mr Hyde?

Figure 2

Non-canonical nuclear factor- κ B signaling in different cell types in rheumatoid arthritis: Dr Jekyll or Mr Hyde? Schematic overview of the role of the non-canonical nuclear factor (NF)-κB pathway in cell types involved in the pathogenesis of rheumatoid arthritis. On the left side (Dr Jekyll), cells in which non-canonical NF-κB signaling plays an anti-inflammatory role. In the middle (on the dashed line), cells in which this pathway plays a dual role, which is largely dependent on the microenvironment. On the right side (Mr Hyde), cells in which non-canonical NF-κB signaling is pro-inflammatory. Treg, regulatory T cell.

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