Non-canonical nuclear factor-
B signaling in different cell types in rheumatoid arthritis: Dr Jekyll or Mr Hyde? Schematic overview of the role of the non-canonical nuclear factor (NF)-κB pathway in cell types involved in the pathogenesis of rheumatoid arthritis. On the left side (Dr Jekyll), cells in which non-canonical NF-κB signaling plays an anti-inflammatory role. In the middle (on the dashed line), cells in which this pathway plays a dual role, which is largely dependent on the microenvironment. On the right side (Mr Hyde), cells in which non-canonical NF-κB signaling is pro-inflammatory. Treg, regulatory T cell.