Parietal and intravascular innate mechanisms of vascular inflammation

Table 2 Humoral innate response and complement in vascular inflammation

Antibody	Activation pathway	Pathogenic role	References
CRP	Classical	• Binds to oxidized lipoproteins or apoptotic cells in atherosclerosis together with terminal complement complex	[61]
PTX3	Classical alternative	• Supposed protective role in atherosclerosis	[16,59,60,62,63]
		• Highly expressed in inflamed vessels of small and large vessel vasculitis (function unknown)
MBL	MBL alternative	• Excess or defect in serum levels associate with increased risk of intimal hyperplasia and ischemic cardiopathy in RA, Kawasaki disease and in the general population	[53,54,64-68]
		• Implication in the activation of complement and in microbial clearance in IgA vasculitis
		• Marginal role in GCA, AAV and Behçet’s disease

AAV, anti-neutrophil cytoplasmic antibody-associated vasculitides; CRP, C-reactive protein; GCA, giant cell arteritis; MBL, mannose binding lectin; PTX, pentraxin; RA, rheumatoid arthritis.

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