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Figure 4 | Arthritis Research & Therapy

Figure 4

From: Kinetics of gene expression and bone remodelling in the clinical phase of collagen-induced arthritis

Figure 4

Gene expression networks during osteoblast activity in early and late phases of joint inflammation. A) A network of genes related to osteoblast activity, in particular collagen type I assembly and cross-linking, during the early phase of clinical disease. Colours and colour intensity indicate upregulation (red) or downregulation (green) regulation of genes at day 0 to 3, where most of the genes showed the greatest fold change in comparison to non-induced controls. One exception is Dmp1, which became upregulated at week 3 to 4. B) A network of genes related to osteoblast activity, in particular mineralisation, during the late phase of clinical disease. Colours and colour intensity indicate upregulation (red) or downregulation (green) regulation of genes at week 1 to 2, where most of the genes showed the greatest fold change in comparison to non-induced controls. One exception is Ibsp, which was most highly upregulated in week 3 to 4.

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