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Table 2 The modified O’Driscoll histologic score

From: Full-thickness cartilage defects are repaired via a microfracture technique and intraarticular injection of the small-molecule compound kartogenin

Characteristic

Grading

I. % Hyaline cartilage

80–100

Score

 

60–80

8

 

40–60

6

 

20–40

4

 

0–20

2

II. Structural characteristics

 

0

A. Surface irregularity

Smooth and intact

 
 

Fissures

2

 

Severe disruption, fibrillation

1

B. Structural integrity

Normal

0

 

Slight disruption, including cysts

2

 

Severe lack of integration

1

C. Thickness

100% of normal adjacent cartilage

0

 

50% to 100% or thicker than normal

2

 

0–50%

1

D. Bonding to adjacent cartilage

Bonded at both ends of graft

0

 

Bonded at one end/partially both ends

2

 

Not bonded

1

III. Freedom from cellular changes of degeneration

Normal cellularity, no clusters

0

 

Slight hypocellularity, <25% chondrocyte clusters

2

 

Moderate hypocellularity, >25% clusters

1

IV. Freedom from degenerate changes in adjacent cartilage

Normal cellularity, no clusters, normal staining

0

 

Normal cellularity, mild clusters, moderate staining

3

 

Mild or mod hypocellularity, slight staining

2

 

Severe hypocellularity, slight staining

1

V. Reconstitution of subchondral bone

Complete reconstitution

0

 

Greater than 50% recon

2

 

50% or less recon

1

VI. Bonding of repair cartilage to de novo subchondral bone

Complete and uninterrupted

0

 

<100% but >50% recon

2

 

<50% complete

1

VII. Safrinin O staining

>80% homogeneous positive stain

0

 

40%–80% homogeneous positive stain

2

 

<40% homogeneous positive stain

1

 

Total score

0

  

Max27