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Table 4 Results of histological evaluation at 3 months

From: Full-thickness cartilage defects are repaired via a microfracture technique and intraarticular injection of the small-molecule compound kartogenin

  Mean score ± SD   95% Confidence interval
Variable Group 1 Group 2 P value Lower limit Upper limit
%Hyaline cartilage 4.7 ± 3.0 1.0 ± 1.1 0.019* 0.75 6.58
Structural characteristics 6.0 ± 0.6 3.2 ± 2.0 0.009* 0.89 4.78
Freedom from cellular changes of degeneration 1.8 ± 0.4 1.2 ± 1.0 0.156 −0.30 1.64
Freedom from degenerate changes in adjacent cartilage 1.7 ± 0.8 1.3 ± 0.5 0.419 −0.55 1.21
Reconstitution of subchondral bone 1.5 ± 0.6 0.5 ± 0.6 0.010* 0.30 1.71
Bonding of repair cartilage to de novo subchondral bone 1.5 ± 0.6 0.8 ± 0.8 0.110 −0.18 1.53
Safrinin O staining 1.3 ± 0.8 0.3 ± 0.5 0.030* 0.12 1.88
Total 18.5 ± 4.2 8.3 ± 4.6 0.003* 4.46 15.87
  1. *Statistically significant difference.