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Figure 1 | Arthritis Research & Therapy

Figure 1

From: Regulatory T cell-deficient scurfy mice develop systemic autoimmune features resembling lupus-like disease

Figure 1

Scurfy mice spontaneously develop severe autoimmune lupus-like skin inflammation. We observed an inflammatory skin disease in scurfy mice that was a consequence of uncontrolled T cell expansion. A macroscopic view of scurfy (Sc) mouse and wild-type (WT) littermate control on day 21 of life (a) and a closer view of the tails of WT mouse (b) and scurfy mouse (c) are shown. Histological examination revealed interface dermatitis with effacement of the dermoepidermal junction and strong lymphohistiocytic inflammatory infiltrates, both of which are key histological features of cutaneous lupus erythematosus. Representative hematoxylin and eosin–stained sections of back skin of WT mouse (d) and sick scurfy mouse (e), as well as a higher magnification image of inflammatory infiltrate in scurfy skin (f), are also shown. (g) Summary of skin pathology scores of scurfy (n = 13) and WT (n = 13) back skin. Representative direct immunofluorescence images show scurfy (h) and WT (i) back skin tissue sections showing linear deposits of murine immunoglobulin only in scurfy skin.

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