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Figure 5 | Arthritis Research & Therapy

Figure 5

From: Regulatory T cell-deficient scurfy mice develop systemic autoimmune features resembling lupus-like disease

Figure 5

Arthritis in scurfy, but not wild-type, joints . All scurfy (Sc; nine of nine), but no control (wild type (WT); zero of nine) mice developed arthritis, as indicated by an inflammatory infiltrate (P < 0.0001). (a) Typical hematoxylin and eosin–stained cross-sections of the hind paws of a scurfy mouse (right panel) and a WT mouse (left panel) are shown. In addition, scurfy mice showed increased cartilage degradation (toluidine blue (TB) staining in (b)), but no osteoclasts were detected within the joint, and therefore no erosions were found (tartrate-resistant acid phosphatase (TRAP) staining in (c)). (d) Graphed data of the quantitative analysis of inflamed area, cartilage damage and eroded area in scurfy and WT mice are shown. The results are shown as mean ± SD for scurfy (n = 9) and WT mice (n = 9). P-values are given in the figure.

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Arthritis Research & Therapy

ISSN: 1478-6362

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