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Figure 6 | Arthritis Research & Therapy

Figure 6

From: Regulatory T cell-deficient scurfy mice develop systemic autoimmune features resembling lupus-like disease

Figure 6

T cells dominate the inflammatory infiltrate in arthritis in scurfy mice . As a consequence of the unleashed T cell proliferation in this regulatory T cell (Treg)-deficient mouse model, the inflammatory infiltrate was dominated by T cells with lower frequencies of granulocytes. (a) A representative immunohistochemical analysis of the hind paw of a scurfy mouse stained with anti-CD3 (upper panel) and neutrophil marker anti-Ly6-B.2 (lower panel) is shown. The quantitative analysis of the inflammatory cellular infiltrate was done by tissue cytometry. A representative scurfy joint is shown in (b) and summarized in (c). T, T cells; B, B cells; mfi, Mean fluorescence intensity; N, Neutrophils; M, Macrophages. The results are shown as mean ± SD for scurfy mice.

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Arthritis Research & Therapy

ISSN: 1478-6362

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