Figure 3

Functional mechanical properties of Phase 1 and 2 neocartilage. In Phase 1, the compressive stiffness (aggregate modulus), tensile stiffness (Young’s modulus), and ultimate tensile strength were significantly enhanced with T3 and T4 treatments during week 1. PTH treatment during either week did not have an effect on construct mechanical properties. In Phase 2, T3 elicited significant increases in compressive and tensile properties. When applied sequentially after T3 in Phase 2, PTH did not alter the T3-induced improvements in mechanical properties. Groups not connected by the same letter are statistically significant. Data are represented as mean ± standard deviation. PTH, parathyroid hormone; T3, tri-iodothyronine; T4, thyroxine.