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Table 1 Dominant metabolic pathways in resting and activated T cells

From: T-cell metabolism in autoimmune disease

Metabolic pathway Naïve resting cells Effector cells Memory cells
Glycolysis + +++ +
Pentose phosphate pathway + +++ ?
Tricarboxylic acid cycle ++ ++ +++
Oxidative phosphorylation ++ + ++
Glutaminolysis + +++ ?
Fatty acid oxidation ++ −/+ ++
  1. +, Mild activity; ++, high activity; +++, intensive activity; −/+, context-dependent activity; ?, unknown.
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Arthritis Research & Therapy

ISSN: 1478-6362

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