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Table 1 Dominant metabolic pathways in resting and activated T cells

From: T-cell metabolism in autoimmune disease

Metabolic pathway

Naïve resting cells

Effector cells

Memory cells

Glycolysis

+

+++

+

Pentose phosphate pathway

+

+++

?

Tricarboxylic acid cycle

++

++

+++

Oxidative phosphorylation

++

+

++

Glutaminolysis

+

+++

?

Fatty acid oxidation

++

−/+

++

  1. +, Mild activity; ++, high activity; +++, intensive activity; −/+, context-dependent activity; ?, unknown.