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Figure 3 | Arthritis Research & Therapy

Figure 3

From: Transcriptome analysis of ageing in uninjured human Achilles tendon

Figure 3

Top-scoring networks derived from the 325 genes differentially expressed in ageing. (A) Ingenuity pathway analysis (IPA) identified from cellular function and maintenance as the principal associated network functions with scores of 43. (B) The second top-scoring network was a cellular growth and proliferation, with scores of 32. (C) IPA identified cell cycle and skeletal and muscular system development function with a score of 32. (D) The fourth top-scoring network was cellular development, with a score of 28. Figures are graphical representations between molecules identified in our data in their respective networks. Green nodes indicate upregulated gene expression in older tendon; red nodes indicate downregulated gene expression in older tendon. Intensity of colour is related to higher fold change. The key to the main features in the networks is shown.

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