Table 9 Significant gene ontology terms annotated according to DAVID’s SP-PIR-Keywords
From: Transcriptome analysis of ageing in uninjured human Achilles tendon
Term | Count | Percentage | P value |
|---|---|---|---|
GO terms identified in downregulated isoforms in old tendon | |||
Signal | 88 | 45.1 | 6.30 × 10−18 |
Secreted | 58 | 29.7 | 7.04 × 10−15 |
Extracellular matrix | 24 | 12.3 | 3.25 × 10−14 |
Glycoprotein | 85 | 43.6 | 2.72 × 10−9 |
Collagen | 12 | 6.2 | 1.62 × 10−7 |
Trimer | 7 | 3.6 | 8.71 × 10−6 |
Hydroxylation | 9 | 4.6 | 2.22 × 10−5 |
Triple helix | 7 | 3.6 | 2.00 × 10−5 |
Hydroxylysine | 7 | 3.6 | 2.00 × 10−5 |
Disulfide bond | 57 | 29.2 | 1.85 × 10−5 |
Cell adhesion | 18 | 9.2 | 3.57 × 10−5 |
Hydroxyproline | 7 | 3.6 | 4.38 × 10−5 |
Ehlers-Danlos syndrome | 5 | 2.6 | 7.34 × 10−5 |
Angiogenesis | 6 | 3.1 | 0.011506 |
Metalloprotease | 8 | 4.1 | 0.016954 |
Pyroglutamic acid | 5 | 2.6 | 0.021871 |
GO terms identified in upregulated isoforms in old tendon | |||
Secreted | 30 | 24.2 | 1.48 × 10−4 |
Plasma | 7 | 5.6 | 0.003767 |
Signal | 39 | 31.5 | 0.006761 |
Acute phase | 4 | 3.2 | 0.052997 |