Figure 1From: Effect of alendronate on post-traumatic osteoarthritis induced by anterior cruciate ligament rupture in mice Representative frontal plane cross-sectional images of the distal femoral epiphysis of injured and sham knees from each of the treatment groups (from micro-computed tomography reconstructions). Knee injury initiated trabecular bone loss in the femoral epiphysis by 7Â days post-injury, but this was largely mitigated by high-dose alendronate (ALN) treatment. Injured knees also exhibited increased subchondral bone thickness by 56Â days post-injury, but this was also partially blocked by high-dose ALN treatment. ALN treatment also increased mineralized tissue volume in the metaphysis, likely due to decreased resorption of growth plate cartilage.Back to article page