Figure 3

Injured knees all exhibited considerable osteophyte formation at 56 days post-injury. Left: inferior images of the distal femur showing the typical pattern of osteophytes. New bone formation occurred primarily from the anterior-medial femur, the posterior-medial tibia, and the medial meniscus. Right: alendronate (ALN) treatment was not effective at preventing osteophyte formation in injured knees. In fact, there was a trend toward increased osteophyte formation in high-dose ALN (ALN-H)-treated animals, although this increase was not statistically significant. ALN-L, low-dose alendronate; VEH, vehicle.