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Table 1 Comparison of clinical manifestations between dermatomyositis patients with acute/subacute interstitial pneumonia and without acute/subacute interstitial pneumonia a

From: Serum progranulin levels are elevated in dermatomyositis patients with acute interstitial lung disease, predicting prognosis

Variables

DM with A/SIP

DM with CIP

DM without ILD

Number of patients

17

24

16

Age, yr

54.0 (36 to 65)

54.5 (19 to 78)

36 (15 to 85)

Female, n (%)

14 (82.4)

20 (83.3)

15 (93.8)

Duration, mo

2 (1 to 19)

33 (1 to 148)***

11 (1 to 237)**

Muscle weakness, n (%)

4 (23.5)

15 (62.5)*

15 (94.1)***

WBCs, count/ml

5,200 (2,900 to 12,300)

8,165 (2,900 to 14,990)

7,590 (3,540 to 11,580)

Hb, g/dl

11.6 (7.9 to 13.9)

12.8 (10 to 15.4)

12.5 (9.8 to 15.3)

Plt, ×105/μl

22.2 (14.9 to 34.5)

23.0 (12 to 38.8)

20.6 (6.2 to 37.7)

CK, IU/L

209 (33 to 866)

1,289 (16 to 12,300)

568 (51 to 2,646)

AST, IU/L

74 (31 to 219)

30 (14 to 657)**

44 (12 to 132)*

ALT, IU/L

42 (19 to 111)

20 (11 to 301)*

31 (10 to 150)

γ-GTP, IU/L

43 (16 to 346)

24 (10 to 131)

26 (10 to 165)

LDH, IU/L

392 (225 to 957)

273 (186 to 1,975)*

328 (157 to 489)*

Ferritin, ng/ml

875 (251 to 2,171)

88 (16 to 4,853)***

105 (39 to 400)***

KL-6, U/ml

959 (338 to 2,048)

525 (188 to 1,802)*

224 (125 to 459)***

PGRN, ng/ml

228 (70 to 586)

75 (43 to 221)***

79 (31 to 207)***

CRP, mg/dl

0.86 (0.03 to 2.97)

0.24 (0.03 to 3.66)**

0.08 (0.01 to 0.9)***

ANA >160, n (%)

1 (5.9)

2 (8.3)

5 (31.3)

Anti-Jo-1, n (%)

0 (0)

4 (16.7)

0 (0)

  1. aANA, Anti-nuclear antibody; A/SIP, Acute/subacute interstitial pneumonia; ALT, Alanine aminotransferase; AST, Aspartate aminotransferase; CIP, Chronic interstitial pneumonia; CK, Creatine kinase; CRP, C-reactive protein; DM, Dermatomyositis; γ-GTP, γ-glutamyl transpeptidase; Hb, Hemoglobin; ILD, Interstitial lung disease; KL-6, Krebs von den Lungen-6; LDH, Lactate dehydrogenase; Plt, Platelets; WBC, White blood cell. The values of age, duration, CK, AST, ALT, γ-GTP, LDH, ferritin, KL-6, PGRN and CRP indicate median (range). *P <0.05, **P <0.01, ***P <0.001 compared with DM with A/SIP using the Mann–Whitney U test or Fisher’s exact test.