Table 1 Relative efficacy versus placebo
| Â | Diclofenac 150Â mg | Celecoxib 200Â mg | Naproxen 1,000Â mg | Etoricoxib 60Â mg | Ibuprofen 2,400Â mg | Acetaminophen 4,000Â mg | ||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Â | Diff CFB (95% CrI) | Prob. better than placebo | Diff CFB (95% CrI) | Prob. better than placebo | Diff CFB (95% CrI) | Prob. better than placebo | Diff CFB (95% CrI) | Prob. better than placebo | Diff CFB (95% CrI) | Prob. better than placebo | Diff CFB (95% CrI) | Prob. better than placebo |
Pain VAS 6 weeks | −13.5 (−16.7; −10.4) | >99% | −8.9 (−10.2; −7.6) | >99% | −10.1 (−12.0; −8.2) | >99% | −13.4 (−17.2; −9.7) | >99% | −10.4 (−13.9; −6.8) | >99% | −4.5 (−7.6; −1.3) | >99% |
Pain VAS 12 weeks | −12.3 (−17.3; −7.4) | >99% | −7.2 (−8.8; −5.7) | >99% | −9.0 (−10.7; −7.3) | >99% | −9.0 (−12.1; −6.1) | >99% | −7.8 (−12.7; −3.0) | >99% | −4.2 (−12.9; 4.4) | 83% |
Pain Likert 6 weeks | −1.8 (−2.4; −1.2) | >99% | −1.4 (−1.7; −1.1) | >99% | −1.9 (−2.7; −1.2) | >99% | NA | NA | NA | NA | NA | NA |
Pain Likert 12 weeks | NA | NA | −1.2 (−1.5; −1.0) | >99% | −1.2 (−1.6; −0.8) | >99% | NA | NA | NA | NA | NA | NA |
PF VAS 6 weeks | −7.7 (−11.9; −3.4) | >99% | −7.9 (−9.8; −6.0) | >99% | −10.5 (−13.0; −8.1) | >99% | −10.2 (−14.4; −5.9) | >99% | −8.9 (−12.7; −5.1) | >99% | −2.4 (−8.4; 3.6) | 79% |
PF VAS 12 weeks | −4.5 (−12.4; 3.1) | 88% | −6.8 (−9.3; −4.9) | >99% | −10.6 (−13.1; −8.0) | >99% | −10.3 (−14.1; −6.6) | >99% | −7.8 (−12.6; −3.2) | >99% | 2.5 (−5.0; 10.2) | 25% |
PF Likert 6 weeks | −6.7 (−9.1; −4.4) | >99% | −4.6 (−5.6; −3.6) | >99% | −3.5 (−5.4; −1.7) | >99% | NA | NA | NA | NA | NA | NA |
PF Likert 12 weeks | NA | NA | −4.6 (−5.6; −3.6) | >99% | −4.0 (−5.0; −3.0) | >99% | NA | NA | NA | NA | NA | NA |
PGA VAS 6 weeks | −15.3 (−25.4; −5.2) | >99% | −9.6 (−12.0; −7.1) | >99% | −9.0 (−12.7; −5.2) | >99% | −9.4 (−15.9; −2.8) | >99% | −11.6 (−16.2; −7.0) | >99% | NA | NA |
PGA VAS 12 weeks | NA | NA | −7.5 (−9.4; −5.7) | >99% | −9.3 (−11.8; −6.8) | >99% | −10.2 (−13.5; −6.9) | >99% | −8.2 (−13.4; −3.0) | >99% | NA | NA |
PGA Likert 6 weeks | −0.5 (−0.9; −0.1) | >99% | −0.2 (−0.5; 0.0) | 97% | −0.4 (−0.6; −0.2) | >99% | NA | NA | NA | NA | NA | NA |
PGA Likert 12 weeks | NA | NA | −0.4 (−0.6; −0.2) | >99% | −0.5 (−0.6; −0.3) | >99% | NA | NA | −0.4 (−0.8; 0.0) | 98% | NA | NA |