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Table 1 Relative efficacy versus placebo

From: Relative benefit-risk comparing diclofenac to other traditional non-steroidal anti-inflammatory drugs and cyclooxygenase-2 inhibitors in patients with osteoarthritis or rheumatoid arthritis: a network meta-analysis

  Diclofenac 150 mg Celecoxib 200 mg Naproxen 1,000 mg Etoricoxib 60 mg Ibuprofen 2,400 mg Acetaminophen 4,000 mg
  Diff CFB (95% CrI) Prob. better than placebo Diff CFB (95% CrI) Prob. better than placebo Diff CFB (95% CrI) Prob. better than placebo Diff CFB (95% CrI) Prob. better than placebo Diff CFB (95% CrI) Prob. better than placebo Diff CFB (95% CrI) Prob. better than placebo
Pain VAS 6 weeks −13.5 (−16.7; −10.4) >99% −8.9 (−10.2; −7.6) >99% −10.1 (−12.0; −8.2) >99% −13.4 (−17.2; −9.7) >99% −10.4 (−13.9; −6.8) >99% −4.5 (−7.6; −1.3) >99%
Pain VAS 12 weeks −12.3 (−17.3; −7.4) >99% −7.2 (−8.8; −5.7) >99% −9.0 (−10.7; −7.3) >99% −9.0 (−12.1; −6.1) >99% −7.8 (−12.7; −3.0) >99% −4.2 (−12.9; 4.4) 83%
Pain Likert 6 weeks −1.8 (−2.4; −1.2) >99% −1.4 (−1.7; −1.1) >99% −1.9 (−2.7; −1.2) >99% NA NA NA NA NA NA
Pain Likert 12 weeks NA NA −1.2 (−1.5; −1.0) >99% −1.2 (−1.6; −0.8) >99% NA NA NA NA NA NA
PF VAS 6 weeks −7.7 (−11.9; −3.4) >99% −7.9 (−9.8; −6.0) >99% −10.5 (−13.0; −8.1) >99% −10.2 (−14.4; −5.9) >99% −8.9 (−12.7; −5.1) >99% −2.4 (−8.4; 3.6) 79%
PF VAS 12 weeks −4.5 (−12.4; 3.1) 88% −6.8 (−9.3; −4.9) >99% −10.6 (−13.1; −8.0) >99% −10.3 (−14.1; −6.6) >99% −7.8 (−12.6; −3.2) >99% 2.5 (−5.0; 10.2) 25%
PF Likert 6 weeks −6.7 (−9.1; −4.4) >99% −4.6 (−5.6; −3.6) >99% −3.5 (−5.4; −1.7) >99% NA NA NA NA NA NA
PF Likert 12 weeks NA NA −4.6 (−5.6; −3.6) >99% −4.0 (−5.0; −3.0) >99% NA NA NA NA NA NA
PGA VAS 6 weeks −15.3 (−25.4; −5.2) >99% −9.6 (−12.0; −7.1) >99% −9.0 (−12.7; −5.2) >99% −9.4 (−15.9; −2.8) >99% −11.6 (−16.2; −7.0) >99% NA NA
PGA VAS 12 weeks NA NA −7.5 (−9.4; −5.7) >99% −9.3 (−11.8; −6.8) >99% −10.2 (−13.5; −6.9) >99% −8.2 (−13.4; −3.0) >99% NA NA
PGA Likert 6 weeks −0.5 (−0.9; −0.1) >99% −0.2 (−0.5; 0.0) 97% −0.4 (−0.6; −0.2) >99% NA NA NA NA NA NA
PGA Likert 12 weeks NA NA −0.4 (−0.6; −0.2) >99% −0.5 (−0.6; −0.3) >99% NA NA −0.4 (−0.8; 0.0) 98% NA NA
  1. Pain VAS, PF VAS, and PGA VAS are in mm. Pain Likert scale runs from 0 to 20, PF Likert scale runs from 0 to 68, PGA Likert scale runs from 0 to 5. CFB, change from baseline; CrI, credible interval; VAS, visual analogue scale; PF, physical functioning; PGA, patient global assessment; NA, data not available.