TY - JOUR AU - Kostopoulou, Fotini AU - Malizos, Konstantinos N. AU - Papathanasiou, Ioanna AU - Tsezou, Aspasia PY - 2015 DA - 2015/03/05 TI - MicroRNA-33a regulates cholesterol synthesis and cholesterol efflux-related genes in osteoarthritic chondrocytes JO - Arthritis Research & Therapy SP - 42 VL - 17 IS - 1 AB - Several studies have shown that osteoarthritis (OA) is strongly associated with metabolism-related disorders, highlighting OA as the fifth component of the metabolic syndrome (MetS). On the basis of our previous findings on dysregulation of cholesterol homeostasis in OA, we were prompted to investigate whether microRNA-33a (miR-33a), one of the master regulators of cholesterol and fatty acid metabolism, plays a key role in OA pathogenesis. SN - 1478-6354 UR - https://doi.org/10.1186/s13075-015-0556-y DO - 10.1186/s13075-015-0556-y ID - Kostopoulou2015 ER -