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Table 1 Demographics and baseline clinical characteristics (per-protocol set)

From: Comparison of two hyaluronic acid formulations for safety and efficacy (CHASE) study in knee osteoarthritis: a multicenter, randomized, double-blind, 26-week non-inferiority trial comparing Durolane to Artz

  Artz Durolane
  ( n= 158) ( n= 161)
Age (years)   
 Number 158 161
 Mean (standard deviation) 60.4 (7.75) 60.2 (8.06)
 Minimum; maximum 42; 78 40; 78
Sex (female) 127 (80.4) 119 (73.9)
Body mass index classification   
 Underweight 0 (0.0) 1 (0.6)
 Normal range 76 (48.1) 81 (50.3)
 Overweight 69 (43.7) 65 (40.4)
 Obese 13 (8.2) 14 (8.7)
Duration of disease (months)   
 Number 157 161
 Mean (standard deviation) 47.7 (57.59) 47.2 (63.15)
 Median 22.2 17.6
ACR criteria   
 Significant knee pain most days during the last 3 months 158 (100%) 161 (100%)
 Age >50 years 147 (93.0%) 147 (91.3%)
 Morning stiffness <30 minutes 129 (81.6%) 127 (78.9%)
 Crepitus on motion 141 (89.2%) 148 (91.9%)
Surgical history   
 Intra-articular steroid injection 5 (3.2%) 5 (3.1%)
 Intra-articular hyaluronic acid injection 28 (17.7%) 36 (22.4%
 Arthroscopy and/or other surgical procedure 8 (5.1%) 4 (2.5%)
 No treatment 122 (77.2%) 118 (73.3%)
X-ray examination   
 II: definite osteophyte, unimpaired joint space 95 (60.1%) 94 (58.4%)
 III: moderate diminution of joint space 63 (39.9%) 67 (41.6%)
Likert-type WOMAC subscalesa   
 Pain (range 0 to 20) 9.5 (1.80) 9.4 (1.98)
 Physical function (range 0 to 68) 22.7 (8.00) 22.3 (8.38)
 Knee stiffness (range 0 to 8) 3.1 (1.77) 2.8 (1.73)
Global self-assessmentb (range 0 to 10) 4.3 (2.06) 4.3 (1.97)
  1. Data presented as number, n (%) or mean (standard deviation) unless stated otherwise. Durolane from Q-med AB (Sweden) and Artz from Seikagaku Corporation (Japan). ACR, American College of Rheumatology; WOMAC, Western Ontario McMasters University Osteoarthritis Index. aLower scores better. bHigher scores better.