Table 2 Summary of changes of all region perfusion responses by treatment and time under normal conditions
Placebo | Ambrisentan | ||||||
|---|---|---|---|---|---|---|---|
Measure | Change period | Change (95% CI) | Change P -value | Overall P -value | Change (95% CI) | Change P -value | Overall P -value |
All | 1 W - Base | 0.18 (−0.27,0.63) | 0.42 | 0.54 | 0.11 (−0.15,0.37) | 0.41 | 0.61 |
12 W - Base | −0.06 (−0.51,0.39) | 0.80 | −0.01 (−0.28,0.25) | 0.93 | |||
12 W - 1 W | −0.24 (−0.69,0.21) | 0.29 | −0.12 (−0.38,0.15) | 0.37 | |||
R1 | 1 W - Base | 0.23 (−0.18,0.64) | 0.26 | 0.29 | 0.12 (−0.11,0.36) | 0.29 | 0.30 |
12 W - Base | −0.08 (−0.48,0.33) | 0.71 | −0.06 (−0.30,0.18) | 0.62 | |||
12 W - 1 W | −0.31 (−0.71,0.10) | 0.14 | −0.18 (−0.42,0.06) | 0.13 | |||
R2 | 1 W - Base | 0.15 (−0.32,0.62) | 0.52 | 0.76 | 0.03 (−0.24,0.31) | 0.80 | 0.80 |
12 W - Base | 0.00 (−0.47,0.47) | 0.99 | −0.06 (−0.34,0.22) | 0.68 | |||
12 W - 1 W | −0.15 (−0.62,0.32) | 0.53 | −0.09 (−0.37,0.19) | 0.51 | |||
R3 | 1 W - Base | 0.08 (−0.42,0.57) | 0.76 | 0.79 | 0.12 (−0.17,0.40) | 0.40 | 0.70 |
12 W - Base | −0.09 (−0.59,0.40) | 0.71 | 0.05 (−0.24,0.34) | 0.71 | |||
12 W - 1 W | −0.17 (−0.66,0.33) | 0.50 | −0.07 (−0.36,0.23) | 0.65 | |||
R4 | 1 W - Base | 0.27 (−0.26,0.80) | 0.31 | 0.42 | 0.15 (−0.16,0.45) | 0.33 | 0.57 |
12 W - Base | −0.06 (−0.59,0.47) | 0.81 | 0.02 (−0.30,0.33) | 0.91 | |||
12 W - 1 W | −0.33 (−0.86,0.20) | 0.22 | −0.13 (−0.45,0.18) | 0.40 | |||
Worst | 1 W - Base | 0.18 (−0.20,0.56) | 0.35 | 0.45 | 0.18 (−0.04,0.40) | 0.10 | 0.25 |
12 W - Base | −0.05 (−0.43,0.33) | 0.79 | 0.06 (−0.16,0.29) | 0.57 | |||
12 W - 1 W | −0.23 (−0.61,0.15) | 0.23 | −0.12 (−0.34,0.11) | 0.29 | |||