 
Placebo

Ambrisentan


Measure

Change period

Change (95% CI)

Change
P
value

Overall
P
value

Change (95% CI)

Change
P
value

Overall
P
value


All

1 W  Base

0.18 (−0.27,0.63)

0.42

0.54

0.11 (−0.15,0.37)

0.41

0.61


12 W  Base

−0.06 (−0.51,0.39)

0.80
 
−0.01 (−0.28,0.25)

0.93
 

12 W  1 W

−0.24 (−0.69,0.21)

0.29
 
−0.12 (−0.38,0.15)

0.37
 
R1

1 W  Base

0.23 (−0.18,0.64)

0.26

0.29

0.12 (−0.11,0.36)

0.29

0.30


12 W  Base

−0.08 (−0.48,0.33)

0.71
 
−0.06 (−0.30,0.18)

0.62
 

12 W  1 W

−0.31 (−0.71,0.10)

0.14
 
−0.18 (−0.42,0.06)

0.13
 
R2

1 W  Base

0.15 (−0.32,0.62)

0.52

0.76

0.03 (−0.24,0.31)

0.80

0.80


12 W  Base

0.00 (−0.47,0.47)

0.99
 
−0.06 (−0.34,0.22)

0.68
 

12 W  1 W

−0.15 (−0.62,0.32)

0.53
 
−0.09 (−0.37,0.19)

0.51
 
R3

1 W  Base

0.08 (−0.42,0.57)

0.76

0.79

0.12 (−0.17,0.40)

0.40

0.70


12 W  Base

−0.09 (−0.59,0.40)

0.71
 
0.05 (−0.24,0.34)

0.71
 

12 W  1 W

−0.17 (−0.66,0.33)

0.50
 
−0.07 (−0.36,0.23)

0.65
 
R4

1 W  Base

0.27 (−0.26,0.80)

0.31

0.42

0.15 (−0.16,0.45)

0.33

0.57


12 W  Base

−0.06 (−0.59,0.47)

0.81
 
0.02 (−0.30,0.33)

0.91
 

12 W  1 W

−0.33 (−0.86,0.20)

0.22
 
−0.13 (−0.45,0.18)

0.40
 
Worst

1 W  Base

0.18 (−0.20,0.56)

0.35

0.45

0.18 (−0.04,0.40)

0.10

0.25


12 W  Base

−0.05 (−0.43,0.33)

0.79
 
0.06 (−0.16,0.29)

0.57
 

12 W  1 W

−0.23 (−0.61,0.15)

0.23
 
−0.12 (−0.34,0.11)

0.29
 
 The ROIs are mentioned as R1 to R4 along with the area of worst perfusion, measured over the study duration. Pvalues are from repeated measure analysis of variance models. Base = baseline; W = week; Worst = worst perfusion. CI, confidence interval; ROI, region of interest.