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Table 2 Summary of changes of all region perfusion responses by treatment and time under normal conditions

From: Evaluation of the effect of ambrisentan on digital microvascular flow in patients with systemic sclerosis using laser Doppler perfusion imaging: a 12-week randomized double-blind placebo controlled trial

   Placebo Ambrisentan
Measure Change period Change (95% CI) Change P -value Overall P -value Change (95% CI) Change P -value Overall P -value
All 1 W - Base 0.18 (−0.27,0.63) 0.42 0.54 0.11 (−0.15,0.37) 0.41 0.61
  12 W - Base −0.06 (−0.51,0.39) 0.80   −0.01 (−0.28,0.25) 0.93  
  12 W - 1 W −0.24 (−0.69,0.21) 0.29   −0.12 (−0.38,0.15) 0.37  
R1 1 W - Base 0.23 (−0.18,0.64) 0.26 0.29 0.12 (−0.11,0.36) 0.29 0.30
  12 W - Base −0.08 (−0.48,0.33) 0.71   −0.06 (−0.30,0.18) 0.62  
  12 W - 1 W −0.31 (−0.71,0.10) 0.14   −0.18 (−0.42,0.06) 0.13  
R2 1 W - Base 0.15 (−0.32,0.62) 0.52 0.76 0.03 (−0.24,0.31) 0.80 0.80
  12 W - Base 0.00 (−0.47,0.47) 0.99   −0.06 (−0.34,0.22) 0.68  
  12 W - 1 W −0.15 (−0.62,0.32) 0.53   −0.09 (−0.37,0.19) 0.51  
R3 1 W - Base 0.08 (−0.42,0.57) 0.76 0.79 0.12 (−0.17,0.40) 0.40 0.70
  12 W - Base −0.09 (−0.59,0.40) 0.71   0.05 (−0.24,0.34) 0.71  
  12 W - 1 W −0.17 (−0.66,0.33) 0.50   −0.07 (−0.36,0.23) 0.65  
R4 1 W - Base 0.27 (−0.26,0.80) 0.31 0.42 0.15 (−0.16,0.45) 0.33 0.57
  12 W - Base −0.06 (−0.59,0.47) 0.81   0.02 (−0.30,0.33) 0.91  
  12 W - 1 W −0.33 (−0.86,0.20) 0.22   −0.13 (−0.45,0.18) 0.40  
Worst 1 W - Base 0.18 (−0.20,0.56) 0.35 0.45 0.18 (−0.04,0.40) 0.10 0.25
  12 W - Base −0.05 (−0.43,0.33) 0.79   0.06 (−0.16,0.29) 0.57  
  12 W - 1 W −0.23 (−0.61,0.15) 0.23   −0.12 (−0.34,0.11) 0.29  
  1. The ROIs are mentioned as R1 to R4 along with the area of worst perfusion, measured over the study duration. P-values are from repeated measure analysis of variance models. Base = baseline; W = week; Worst = worst perfusion. CI, confidence interval; ROI, region of interest.