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Table 3 Univariate and multivariate association of traditionalcardiovascular risk factors and RA-rated factors with severe subclinical atherosclerosis

From: Significant effects of biologic therapy on lipid profiles and insulin resistance in patients with rheumatoid arthritis

Risk factors (univariate)

Odds ratio

95% confidence interval

P value

Age

1.09

1.04-1.14

0.000

Sex (female)

0.89

0.18-4.39

0.883

Smoking status

3.87

0.79-19.06

0.096

Hypertension Rx.

1.35

0.55-3.32

0.517

Body mass index

0.95

0.86-1.05

0.328

Total cholesterol

1.00

0.98-1.01

0.491

HDL-C

1.01

0.98-1.04

0.467

LDL-C

1.00

0.98-1.01

0.511

Total triglyceride

1.00

0.99-1.02

0.640

Artherogenic index

2.12

1.05-4.25

0.035

Modified FRS

1.20

1.01-1.42

0.033

Insulin resistance

2.43

1.50-3.93

0.000

Disease duration >10 years

3.33

1.36-8.15

0.008

RF positivity

1.41

0.44-4.44

0.562

Anti-CCP positivity

1.44

0.89-2.35

0.142

TNF-α levels

1.00

0.99-1.00

0.743

IL-6 levels

1.00

1.00-1.00

0.196

DAS28

2.94

1.58-5.49

0.001

Risk factors (multivariate)

Odds ratio

95% confidence interval

P value

Age

1.08

1.02-1.15

0.007

Artherogenic index

1.31

0.98-1.76

0.073

Modified FRS

1.17

0.97-1.40

0.093

Insulin resistance

2.77

1.40-5.46

0.003

Disease duration >10 years

5.89

0.93-37.16

0.059

DAS28

2.52

1.00-6.35

0.049

  1. Anti-CCP, anti-cyclic citrullinated peptide (antibodies); DAS28, disease activity score for 28-joints; FRS, Framingham risk score; HDL-C, high-density lipoprotein cholesterol; IL-6, interleukin-6; LDL-C, low-density lipoprotein cholesterol; RF, rheumatoid factor; Rx, treatment; TNF-α, tumor necrosis factor-alpha.