Reasons | Patients experiencing deviation, n (%) | Number of deviations | |
---|---|---|---|
Total frequency (%) | Median (IQR) deviation/patient | ||
Toxicity | Â | Â | Â |
  Gastrointestinal | 46 (23.2) | 80 | 1 (1 to 2) |
  Haematological | 25 (12.6) | 61 | 2 (1 to 3) |
  Central nervous system | 26 (13.1) | 35 | 1 (1 to 2) |
  Abnormal liver function | 18 (9.1) | 28 | 1 (1 to 2) |
  Skin and hair | 13 (6.6) | 16 | 1 (1 to 1) |
  Fatigue | 12 (6.1) | 14 | 1 (1 to 1) |
  Muco-cutaneous | 9 (4.5) | 13 | 1 (1 to 2) |
  Other 1 | 8 (4.0) | 9 | 1 (1 to 1) |
Comorbidities | Â | Â | Â |
  Infection | 28 (14.1) | 45 | 1 (1 to 2) |
  Other co-morbidities 2 | 51 (25.8) | 134 | 2 (1 to 4) |
Patient-related | Â | Â | Â |
  Poor concordance | 71 (35.9) | 106 | 1 (1 to 2) |
  Reluctance to modify therapy | 48 (24.2) | 94 | 1 (1 to 3) |
  Other 3 | 20 (10.1) | 21 | 1 (1 to 1) |
Physician-related | Â | Â | Â |
  Wait and see | 50 (25.3) | 95 | 1 (1 to 3) |
  Limited option | 11 (5.6) | 27 | 1 (1 to 5) |
  Persistent disease 4 | 14 (7.1) | 15 | 2 (1 to 2) |
  Other 5 | 65 (32.8) | 84 | 1 (1 to 2) |
Other 6 | 35 (17.7) | 66 (7.3) | 1 (1 to 2) |