|
US parameter
|
PSS
|
SQuant
|
PQuant
|
PDHi
|
PQuant/SQuant
|
|---|
|
TNF-α
|
0.46*
|
0.74*
|
0.61*
|
0.60*
|
0.59*
|
|
IL-6
|
0.30
|
0.69*
|
0.59*
|
0.56*
|
0.57*
|
|
IL-1β
|
0.47*
|
0.81*
|
0.68*
|
0.64*
|
0.67*
|
|
Podoplanin
|
0.19
|
0.71*
|
0.43
|
0.15
|
0.32
|
|
Angiopoietin 1
|
0.4
|
0.37
|
0.22
|
0.11
|
0.23
|
|
Angiopoietin 2
|
0.5
|
0.74*
|
0.61*
|
0.46
|
0.56*
|
|
VEGF-R3
|
0.50*
|
0.61*
|
0.55*
|
0.36
|
0.47
|
|
VEGF-C
|
0.2
|
0.62*
|
0.39
|
0.14
|
0.29
|
|
VEGF-A
|
0.5
|
0.56*
|
0.52*
|
0.48*
|
0.54*
|
|
Tie-2
|
0.3
|
0.51*
|
0.44
|
0.19
|
0.34
|
|
Synovitis score
|
0.25
|
0.18
|
0.27
|
0.48*
|
0.31
|
|
CD68SL
|
0.29
|
0.35*
|
0.40*
|
0.51*
|
0.40*
|
|
CD68L
|
0.12
|
0.46*
|
0.18
|
0.33
|
0.09
|
|
CD20
|
0.02
|
0.24
|
0.25
|
0.38*
|
0.22
|
- Correlation was analysed using Spearman's rho. *Significant values (P <0.05). SQuant correlated with the majority of pro-inflammatory cytokines, angiogenic, lymphangiogenic gene expression and macrophage lining and sublining infiltration. PSS, power Doppler semiquantitative score; SQuant, quantitative synovial thickness area; PQuant, quantitative power Doppler area; PDHi, quantitative thresholded power Doppler area; VEGF, vascular endothelial growth factor, Tie, Tyrosine kinase (predominant endothelial cell expression), CD68SL, macrophage marker (synovial sublining layer), CD68L, macrophage marker (synovial lining layer).
