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Table 2 Correlation matrix of ultrasound parameters with angiogenic, lymphangiogenic cytokine expression and cellular infiltration

From: Angiogenic gene expression and vascular density are reflected in ultrasonographic features of synovitis in early rheumatoid arthritis: an observational study

US parameter PSS SQuant PQuant PDHi PQuant/SQuant
TNF-α 0.46* 0.74* 0.61* 0.60* 0.59*
IL-6 0.30 0.69* 0.59* 0.56* 0.57*
IL-1β 0.47* 0.81* 0.68* 0.64* 0.67*
Podoplanin 0.19 0.71* 0.43 0.15 0.32
Angiopoietin 1 0.4 0.37 0.22 0.11 0.23
Angiopoietin 2 0.5 0.74* 0.61* 0.46 0.56*
VEGF-R3 0.50* 0.61* 0.55* 0.36 0.47
VEGF-C 0.2 0.62* 0.39 0.14 0.29
VEGF-A 0.5 0.56* 0.52* 0.48* 0.54*
Tie-2 0.3 0.51* 0.44 0.19 0.34
Synovitis score 0.25 0.18 0.27 0.48* 0.31
CD68SL 0.29 0.35* 0.40* 0.51* 0.40*
CD68L 0.12 0.46* 0.18 0.33 0.09
CD20 0.02 0.24 0.25 0.38* 0.22
  1. Correlation was analysed using Spearman's rho. *Significant values (P <0.05). SQuant correlated with the majority of pro-inflammatory cytokines, angiogenic, lymphangiogenic gene expression and macrophage lining and sublining infiltration. PSS, power Doppler semiquantitative score; SQuant, quantitative synovial thickness area; PQuant, quantitative power Doppler area; PDHi, quantitative thresholded power Doppler area; VEGF, vascular endothelial growth factor, Tie, Tyrosine kinase (predominant endothelial cell expression), CD68SL, macrophage marker (synovial sublining layer), CD68L, macrophage marker (synovial lining layer).